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• W3125598042 abstract "The antigen-independent, strong proliferative responses of naive CD8 + T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γ c ) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally high levels in these mice. Similarly, in the present study, we showed that mice lacking Janus kinase 3 (Jak3), a tyrosine kinase crucial for γ c cytokine signaling, could induce strong proliferation of adoptively transferred naive CD8 + T cells. This proliferation was also independent of antigenic stimulation, but heavily dependent on IL-2, as evidenced by the failure of proliferation of adoptively transferred IL-2 receptor alpha- and beta-chain-deficient naive CD8 + T cells. Consistent with this, Jak3 –/– mice showed elevated serum levels of IL-2 compared to wild-type mice, and interestingly, IL-2 production was due to high levels of accumulation of activated CD4 + T cells in Jak3 –/– mice along with defective CD4 + T regulatory cells. Collectively, these findings reveal previously unidentified unique immune contexts of Jak3 –/– mice that cause robust IL-2-driven T cell expansion and have a clinical implication for designing a treatment strategy for human patients with loss-of-function genetic mutations of Jak3 ." @default.
• W3125598042 created "2021-02-01" @default.
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• W3125598042 date "2021-01-28" @default.
• W3125598042 modified "2023-10-18" @default.
• W3125598042 title "Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells" @default.
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• W3125598042 doi "https://doi.org/10.3389/fimmu.2020.616898" @default.
• W3125598042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7876067" @default.
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