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- W3125725344 endingPage "626" @default.
- W3125725344 startingPage "528" @default.
- W3125725344 abstract "This chapter begins with a basic science update on the development of the female reproductive system. This starts with sections on maturation of the neuroendocrine-ovarian axis and regulation of the neuroendocrine-ovarian axis. The former reviews maturation of the hypothalamic-pituitary-ovarian axis during fetal life, infancy and childhood, and adolescence, concluding with mechanisms that underlie the normal adult ovulatory cycle. The regulation section reviews factors controlling the onset of puberty, regulation of gonadotropin secretion, and regulation of ovarian secretion. Following are successive sections on adrenarche and the regulation of adrenal androgen secretion and hormonal secretion, transport, metabolism, and mechanisms of action, the latter covering both peptide and steroid hormones. The basic science update concludes with a review of the maturation of sex hormone target organs covering both the classical and nonclassical effects of sex steroids on their targets. The normal hormonal and sexual maturational changes that culminate in sexual maturity are then detailed from fetal life through the adult menstrual cycle. This section concludes with a discussion of the common normal pubertal variants, including premature thelarche, premature pubarche, constitutional delay of growth and pubertal development, and physiological adolescent anovulation. The last half of the chapter reviews the causes, differential diagnosis, and management of abnormal puberty. The topics covered include precocious puberty, hypogonadism, and nonhypoestrogenic menstrual disturbances, such as hypothalamic anovulation and ovulatory dysfunction as a cause of dysfunctional uterine bleeding. The section concludes with a review of hyperandrogenism in adolescence, emphasizing the most common cause, polycystic ovary syndrome." @default.
- W3125725344 created "2021-02-01" @default.
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- W3125725344 creator A5012068391 @default.
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- W3125725344 date "2021-01-01" @default.
- W3125725344 modified "2023-09-26" @default.
- W3125725344 title "Puberty in the Female and Its Disorders" @default.
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