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• W3125823105 abstract "SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response gene expression was analyzed by qRT-PCR in uninfected Caco-2 intestinal epithelial cells treated with LF. An infection assay for SARS-CoV-2 was performed in Caco-2 cells treated or not with LF. SARS-CoV-2 titer was determined by qRT-PCR, plaque assay and immunostaining. Inflammatory and anti-inflammatory cytokine production was determined by qRT-PCR. LF significantly induced the expression of IFNA1, IFNB1, TLR3, TLR7, IRF3, IRF7 and MAVS genes. Furthermore, LF partially inhibited SARS-CoV-2 infection and replication in Caco-2 intestinal epithelial cells. Our in vitro data support LF as an immune modulator of the antiviral immune response with moderate effects against SARS-CoV-2 infection." @default.
• W3125823105 created "2021-02-01" @default.
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• W3125823105 date "2021-01-23" @default.
• W3125823105 modified "2023-10-05" @default.
• W3125823105 title "Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro" @default.
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• W3125823105 doi "https://doi.org/10.3390/nu13020328" @default.
• W3125823105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7911668" @default.
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