Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125832017> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3125832017 abstract "Abstract Background: Lead (Pb) is a toxic environmental pollutant and can exerts toxicity in kidneys. It is known that selenium (Se) has an antagonistic effect on Pb poisoning. However, biological events during the process were not well understood in chicken kidneys. Methods: One hundred and eighty male Hyline chickens (7-day-old) were randomly divided into the control group (offering standard diet and potable water), the Se group (offering Na 2 SeO 3 -added standard diet and potable water), the Pb group (offering standard diet and (CH 3 OO) 2 Pb-added potable water), and the Pb+Se group (offering Na 2 SeO 3 -added standard diet and (CH 3 OO) 2 Pb-added potable water). On 30 th , 60 th , and 90 th days, kidneys were removed to perform the studies of histological structure, oxidative stress indicators, cytokines, heat shock proteins, and autophagy in the chicken kidneys. Results: The experimental results indicated that Pb poisoning changed renal histological structure; decreased catalase, glutathione-s-transferase, and total antioxidative capacity activities; increased hydrogen peroxide content; induced mRNA and protein expression of heat shock proteins; inhibited interleukin (IL)-2 mRNA expression, and induced IL-4 and IL-12β mRNA expression; inhibited mammalian target of rapamycin mRNA and protein expression, and induced autophagy-related gene mRNA and protein expression in the chicken kidneys. Supplement of Se mitigated the above changes caused by Pb. Conclusion: Our research strengthens the evidence that Pb induced oxidative stress, inflammation, heat shock response, and autophagy and Se administration alleviated Pb poisoning through mitigating oxidative stress in the chicken kidneys." @default.
- W3125832017 created "2021-02-01" @default.
- W3125832017 creator A5026772849 @default.
- W3125832017 creator A5080407917 @default.
- W3125832017 creator A5082548881 @default.
- W3125832017 creator A5086985429 @default.
- W3125832017 creator A5087678696 @default.
- W3125832017 date "2021-01-15" @default.
- W3125832017 modified "2023-09-27" @default.
- W3125832017 title "Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy" @default.
- W3125832017 doi "https://doi.org/10.21203/rs.3.rs-146251/v1" @default.
- W3125832017 hasPublicationYear "2021" @default.
- W3125832017 type Work @default.
- W3125832017 sameAs 3125832017 @default.
- W3125832017 citedByCount "0" @default.
- W3125832017 crossrefType "posted-content" @default.
- W3125832017 hasAuthorship W3125832017A5026772849 @default.
- W3125832017 hasAuthorship W3125832017A5080407917 @default.
- W3125832017 hasAuthorship W3125832017A5082548881 @default.
- W3125832017 hasAuthorship W3125832017A5086985429 @default.
- W3125832017 hasAuthorship W3125832017A5087678696 @default.
- W3125832017 hasBestOaLocation W31258320171 @default.
- W3125832017 hasConcept C104317684 @default.
- W3125832017 hasConcept C105580179 @default.
- W3125832017 hasConcept C126322002 @default.
- W3125832017 hasConcept C134018914 @default.
- W3125832017 hasConcept C16685009 @default.
- W3125832017 hasConcept C181199279 @default.
- W3125832017 hasConcept C185592680 @default.
- W3125832017 hasConcept C190283241 @default.
- W3125832017 hasConcept C203522944 @default.
- W3125832017 hasConcept C205260736 @default.
- W3125832017 hasConcept C2776151105 @default.
- W3125832017 hasConcept C2776914184 @default.
- W3125832017 hasConcept C2778979269 @default.
- W3125832017 hasConcept C533411734 @default.
- W3125832017 hasConcept C538909803 @default.
- W3125832017 hasConcept C55493867 @default.
- W3125832017 hasConcept C71924100 @default.
- W3125832017 hasConcept C86803240 @default.
- W3125832017 hasConcept C98274493 @default.
- W3125832017 hasConceptScore W3125832017C104317684 @default.
- W3125832017 hasConceptScore W3125832017C105580179 @default.
- W3125832017 hasConceptScore W3125832017C126322002 @default.
- W3125832017 hasConceptScore W3125832017C134018914 @default.
- W3125832017 hasConceptScore W3125832017C16685009 @default.
- W3125832017 hasConceptScore W3125832017C181199279 @default.
- W3125832017 hasConceptScore W3125832017C185592680 @default.
- W3125832017 hasConceptScore W3125832017C190283241 @default.
- W3125832017 hasConceptScore W3125832017C203522944 @default.
- W3125832017 hasConceptScore W3125832017C205260736 @default.
- W3125832017 hasConceptScore W3125832017C2776151105 @default.
- W3125832017 hasConceptScore W3125832017C2776914184 @default.
- W3125832017 hasConceptScore W3125832017C2778979269 @default.
- W3125832017 hasConceptScore W3125832017C533411734 @default.
- W3125832017 hasConceptScore W3125832017C538909803 @default.
- W3125832017 hasConceptScore W3125832017C55493867 @default.
- W3125832017 hasConceptScore W3125832017C71924100 @default.
- W3125832017 hasConceptScore W3125832017C86803240 @default.
- W3125832017 hasConceptScore W3125832017C98274493 @default.
- W3125832017 hasLocation W31258320171 @default.
- W3125832017 hasOpenAccess W3125832017 @default.
- W3125832017 hasPrimaryLocation W31258320171 @default.
- W3125832017 hasRelatedWork W1971190995 @default.
- W3125832017 hasRelatedWork W1971892168 @default.
- W3125832017 hasRelatedWork W1976894040 @default.
- W3125832017 hasRelatedWork W1990207011 @default.
- W3125832017 hasRelatedWork W1996973293 @default.
- W3125832017 hasRelatedWork W2123114163 @default.
- W3125832017 hasRelatedWork W2395950097 @default.
- W3125832017 hasRelatedWork W2415504307 @default.
- W3125832017 hasRelatedWork W2589620296 @default.
- W3125832017 hasRelatedWork W3106906779 @default.
- W3125832017 isParatext "false" @default.
- W3125832017 isRetracted "false" @default.
- W3125832017 magId "3125832017" @default.
- W3125832017 workType "article" @default.