Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125854906> ?p ?o ?g. }
- W3125854906 abstract "Francisella tularensis , the causative agent of tularemia, is transmitted by arthropod vectors within mammalian hosts. The detailed mechanisms contributing to growth and survival of Francisella within arthropod remain poorly understood. To identify novel factors supporting growth and survival of Francisella within arthropods, a transposon mutant library of F. tularensis subsp. novicida ( F. novicida ) was screened using an F. novicida –silkworm infection model. Among 750 transposon mutants screened, the mltA -encoding membrane-bound lytic murein transglycosylase A (MltA) was identified as a novel growth factor of F. novicida in silkworms. Silkworms infection with an mltA deletion mutant (Δ mltA ) resulted in a reduction in the number of bacteria and prolonged survival. The Δ mltA strain exhibited limited intracellular growth and cytotoxicity in BmN4 silkworm ovary cells. Moreover, the Δ mltA strain induced higher expression of the antimicrobial peptide in silkworms compared to the wild-type strain. These results suggest that F. novicida MltA contributes to the survival of F. novicida in silkworms via immune suppression-related mechanisms. Intracellular growth of the Δ mltA strain was also reduced in human monocyte THP-1 cells. These results also suggest the contribution of MltA to pathogenicity in humans and utility of the F. novicida –silkworm infection model to explore Francisella infection." @default.
- W3125854906 created "2021-02-01" @default.
- W3125854906 creator A5009660351 @default.
- W3125854906 creator A5010154396 @default.
- W3125854906 creator A5035054795 @default.
- W3125854906 creator A5059138509 @default.
- W3125854906 creator A5063322770 @default.
- W3125854906 creator A5064967440 @default.
- W3125854906 creator A5083376202 @default.
- W3125854906 creator A5085653396 @default.
- W3125854906 date "2021-01-22" @default.
- W3125854906 modified "2023-09-24" @default.
- W3125854906 title "Identification of Membrane-Bound Lytic Murein Transglycosylase A (MltA) as a Growth Factor for Francisella novicida in a Silkworm Infection Model" @default.
- W3125854906 cites W1493876446 @default.
- W3125854906 cites W1511963303 @default.
- W3125854906 cites W1968629193 @default.
- W3125854906 cites W1977521262 @default.
- W3125854906 cites W1978486152 @default.
- W3125854906 cites W1990512275 @default.
- W3125854906 cites W2002954007 @default.
- W3125854906 cites W2012580060 @default.
- W3125854906 cites W2012811488 @default.
- W3125854906 cites W2021743399 @default.
- W3125854906 cites W2022964667 @default.
- W3125854906 cites W2026029780 @default.
- W3125854906 cites W2033548003 @default.
- W3125854906 cites W2041327525 @default.
- W3125854906 cites W2061656821 @default.
- W3125854906 cites W2061953031 @default.
- W3125854906 cites W2064473364 @default.
- W3125854906 cites W2067459912 @default.
- W3125854906 cites W2070780187 @default.
- W3125854906 cites W2087469928 @default.
- W3125854906 cites W2088437374 @default.
- W3125854906 cites W2088916058 @default.
- W3125854906 cites W2106535824 @default.
- W3125854906 cites W2116491724 @default.
- W3125854906 cites W2118435687 @default.
- W3125854906 cites W2121809643 @default.
- W3125854906 cites W2142206735 @default.
- W3125854906 cites W2144142848 @default.
- W3125854906 cites W2146202002 @default.
- W3125854906 cites W2146469860 @default.
- W3125854906 cites W2149534814 @default.
- W3125854906 cites W2157825690 @default.
- W3125854906 cites W2158273859 @default.
- W3125854906 cites W2158691001 @default.
- W3125854906 cites W2167960824 @default.
- W3125854906 cites W2178228629 @default.
- W3125854906 cites W2195221608 @default.
- W3125854906 cites W2300616893 @default.
- W3125854906 cites W2344898050 @default.
- W3125854906 cites W2406093747 @default.
- W3125854906 cites W2475471873 @default.
- W3125854906 cites W2560746362 @default.
- W3125854906 cites W2604469206 @default.
- W3125854906 cites W2621640523 @default.
- W3125854906 cites W2680788573 @default.
- W3125854906 cites W2738584726 @default.
- W3125854906 cites W2765408446 @default.
- W3125854906 cites W2778957670 @default.
- W3125854906 cites W2784153161 @default.
- W3125854906 cites W2805091853 @default.
- W3125854906 cites W2857393172 @default.
- W3125854906 cites W2950997897 @default.
- W3125854906 cites W2998117658 @default.
- W3125854906 cites W4211067865 @default.
- W3125854906 cites W4298223478 @default.
- W3125854906 doi "https://doi.org/10.3389/fcimb.2020.581864" @default.
- W3125854906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7862118" @default.
- W3125854906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33553001" @default.
- W3125854906 hasPublicationYear "2021" @default.
- W3125854906 type Work @default.
- W3125854906 sameAs 3125854906 @default.
- W3125854906 citedByCount "6" @default.
- W3125854906 countsByYear W31258549062021 @default.
- W3125854906 countsByYear W31258549062022 @default.
- W3125854906 countsByYear W31258549062023 @default.
- W3125854906 crossrefType "journal-article" @default.
- W3125854906 hasAuthorship W3125854906A5009660351 @default.
- W3125854906 hasAuthorship W3125854906A5010154396 @default.
- W3125854906 hasAuthorship W3125854906A5035054795 @default.
- W3125854906 hasAuthorship W3125854906A5059138509 @default.
- W3125854906 hasAuthorship W3125854906A5063322770 @default.
- W3125854906 hasAuthorship W3125854906A5064967440 @default.
- W3125854906 hasAuthorship W3125854906A5083376202 @default.
- W3125854906 hasAuthorship W3125854906A5085653396 @default.
- W3125854906 hasBestOaLocation W31258549061 @default.
- W3125854906 hasConcept C104317684 @default.
- W3125854906 hasConcept C159047783 @default.
- W3125854906 hasConcept C182615771 @default.
- W3125854906 hasConcept C2522874641 @default.
- W3125854906 hasConcept C2775983634 @default.
- W3125854906 hasConcept C2780467176 @default.
- W3125854906 hasConcept C2780796267 @default.
- W3125854906 hasConcept C54355233 @default.
- W3125854906 hasConcept C60987743 @default.
- W3125854906 hasConcept C86803240 @default.
- W3125854906 hasConcept C89423630 @default.
- W3125854906 hasConceptScore W3125854906C104317684 @default.