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- W3125872008 abstract "Abstract Background Multiple Sclerosis (MS) is a demyelinating disease leading to long-term neurological deficit due to unsuccessful remyelination and axonal loss. Currently, there are no satisfactory treatments for progressive MS somewhat due to the lack of an adequate animal model for studying the mechanisms of disease progression and screening new drugs. New method Lysolecithin (LPC) or agarose-gel loaded LPC (AL-LPC) were applied to mouse optic nerve behind the globe via a minor surgery. Agarose loading was used to achieve longer time of LPC exposure and subsequently long-lasting demyelination. Results The lesion sites characterized by luxol fast blue (LFB), FluoroMyelin, Bielschowsky’s staining, and immunostaining showed extensive demyelination and axonal damage. The loss of Retinal ganglion cells (RGCs) in the corresponding retinal layer was shown by immunostaining and HE however, these pathologies were more extensive in the AL-LPC group. Conclusion The optimized model provides a longer demyelination time frame and axonal damage followed by RGC degeneration; which is of exceptional interest in investigating axonal degeneration mechanisms and screening the new drugs for progressive MS." @default.
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- W3125872008 date "2021-03-01" @default.
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- W3125872008 title "An optimized animal model of lysolecithin induced demyelination in optic nerve; more feasible, more reproducible, promising for studying the progressive forms of multiple sclerosis" @default.
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- W3125872008 doi "https://doi.org/10.1016/j.jneumeth.2021.109088" @default.
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