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- W3125890353 abstract "Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly highlighted synaptic function and transcriptional regulation as key points of convergence. However, these analyses rely on incomplete knowledge of gene function across brain development. Here we leverage Xenopus tropicalis to study in vivo ten genes with the strongest statistical evidence for association with ASD. All genes are expressed in developing telencephalon at time points mapping to human mid-prenatal development, and mutations lead to an increase in the ratio of neural progenitor cells to maturing neurons, supporting previous in silico systems biological findings implicating cortical neurons in ASD vulnerability, but expanding the range of convergent functions to include neurogenesis. Systematic chemical screening identifies that estrogen, via Sonic hedgehog signaling, rescues this convergent phenotype in Xenopus and human models of brain development, suggesting a resilience factor that may mitigate a range of ASD genetic risks." @default.
- W3125890353 created "2021-02-01" @default.
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- W3125890353 date "2021-03-01" @default.
- W3125890353 modified "2023-10-16" @default.
- W3125890353 title "Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience" @default.
- W3125890353 cites W1520236834 @default.
- W3125890353 cites W1553983967 @default.
- W3125890353 cites W1794962712 @default.
- W3125890353 cites W1915704240 @default.
- W3125890353 cites W1919153237 @default.
- W3125890353 cites W1964444099 @default.
- W3125890353 cites W1964712663 @default.
- W3125890353 cites W1970756199 @default.
- W3125890353 cites W1976222552 @default.
- W3125890353 cites W1978701742 @default.
- W3125890353 cites W1982646269 @default.
- W3125890353 cites W1988670106 @default.
- W3125890353 cites W1992865216 @default.
- W3125890353 cites W2001350050 @default.
- W3125890353 cites W2001910980 @default.
- W3125890353 cites W2007535582 @default.
- W3125890353 cites W2008627757 @default.
- W3125890353 cites W2009742334 @default.
- W3125890353 cites W2011409454 @default.
- W3125890353 cites W2015038624 @default.
- W3125890353 cites W2019826351 @default.
- W3125890353 cites W2020541351 @default.
- W3125890353 cites W2021399360 @default.
- W3125890353 cites W2022689242 @default.
- W3125890353 cites W2024663595 @default.
- W3125890353 cites W2025260963 @default.
- W3125890353 cites W2034102853 @default.
- W3125890353 cites W2035941642 @default.
- W3125890353 cites W2049941486 @default.
- W3125890353 cites W2058166388 @default.
- W3125890353 cites W2059614045 @default.
- W3125890353 cites W2061582515 @default.
- W3125890353 cites W2062274257 @default.
- W3125890353 cites W2068427957 @default.
- W3125890353 cites W2071598557 @default.
- W3125890353 cites W2072595310 @default.
- W3125890353 cites W2073154969 @default.
- W3125890353 cites W2078030440 @default.
- W3125890353 cites W2082107430 @default.
- W3125890353 cites W2085198610 @default.
- W3125890353 cites W2087786585 @default.
- W3125890353 cites W2091989272 @default.
- W3125890353 cites W2094038606 @default.
- W3125890353 cites W2103635980 @default.
- W3125890353 cites W2104407051 @default.
- W3125890353 cites W2106070783 @default.
- W3125890353 cites W2108366237 @default.
- W3125890353 cites W2108994842 @default.
- W3125890353 cites W2112891548 @default.
- W3125890353 cites W2125226755 @default.
- W3125890353 cites W2126924893 @default.
- W3125890353 cites W2128300020 @default.
- W3125890353 cites W2128801071 @default.
- W3125890353 cites W2131104106 @default.
- W3125890353 cites W2137283360 @default.
- W3125890353 cites W2138643777 @default.
- W3125890353 cites W2148280908 @default.
- W3125890353 cites W2153451653 @default.
- W3125890353 cites W2153773863 @default.
- W3125890353 cites W2163302580 @default.
- W3125890353 cites W2166535160 @default.
- W3125890353 cites W2167279371 @default.
- W3125890353 cites W2168175722 @default.
- W3125890353 cites W2169456326 @default.
- W3125890353 cites W2176254324 @default.
- W3125890353 cites W2177815640 @default.
- W3125890353 cites W2179438025 @default.
- W3125890353 cites W2195301576 @default.
- W3125890353 cites W2208796000 @default.
- W3125890353 cites W2271752557 @default.
- W3125890353 cites W2283383082 @default.
- W3125890353 cites W2291794033 @default.
- W3125890353 cites W2295326929 @default.
- W3125890353 cites W2336178310 @default.
- W3125890353 cites W2508602832 @default.