FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125898896> ?p ?o ?g. }

• W3125898896 endingPage "103" @default.
• W3125898896 startingPage "103" @default.
• W3125898896 abstract "Androgen receptor (AR)-null prostate tumors have been observed in 11–24% of patients. Histone deacetylases (HDACs) are overexpressed in prostate tumors. Therefore, HDAC inhibitors (Jazz90 and Jazz167) were examined in AR-null prostate cancer cell lines (PC3 and DU145). Both Jazz90 and Jazz167 inhibited the growth of PC3 and DU145 cells. Jazz90 and Jazz167 were more active in PC3 cells and DU145 cells in comparison to normal prostate cells (PNT1A) and showed a 2.45- and 1.30-fold selectivity and higher cytotoxicity toward DU145 cells, respectively. Jazz90 and Jazz167 reduced HDAC activity by ~60% at 50 nM in PC3 lysates. At 4 μM, Jazz90 and Jazz167 increased acetylation in PC3 cells by 6- to 8-fold. Flow cytometry studies on the cell phase distribution demonstrated that Jazz90 causes a G0/G1 arrest in AR-null cells, whereas Jazz167 leads to a G0/G1 arrest in DU145 cells. However, apoptosis only occurred at a maximum of 7% of the total cell population following compound treatments in PC3 and DU145 cells. There was a reduction in cyclin D1 and no significant changes in bcl-2 in DU145 and PC3 cells. Overall, the results showed that Jazz90 and Jazz167 function as cytostatic HDAC inhibitors in AR-null prostate cancer cells." @default.
• W3125898896 created "2021-02-01" @default.
• W3125898896 creator A5025590518 @default.
• W3125898896 creator A5036498123 @default.
• W3125898896 creator A5078561219 @default.
• W3125898896 creator A5086697134 @default.
• W3125898896 creator A5087288813 @default.
• W3125898896 date "2021-01-29" @default.
• W3125898896 modified "2023-10-16" @default.
• W3125898896 title "Cytostatic Action of Novel Histone Deacetylase Inhibitors in Androgen Receptor-Null Prostate Cancer Cells" @default.
• W3125898896 cites W1967434207 @default.
• W3125898896 cites W1976964015 @default.
• W3125898896 cites W1979228240 @default.
• W3125898896 cites W1984143603 @default.
• W3125898896 cites W2028195490 @default.
• W3125898896 cites W2039139796 @default.
• W3125898896 cites W2040867535 @default.
• W3125898896 cites W2048813174 @default.
• W3125898896 cites W2080244165 @default.
• W3125898896 cites W2101284441 @default.
• W3125898896 cites W2104425103 @default.
• W3125898896 cites W2109689528 @default.
• W3125898896 cites W2116074861 @default.
• W3125898896 cites W2118055719 @default.
• W3125898896 cites W2148718757 @default.
• W3125898896 cites W2149379768 @default.
• W3125898896 cites W2152966058 @default.
• W3125898896 cites W2159368077 @default.
• W3125898896 cites W2161490817 @default.
• W3125898896 cites W2161546209 @default.
• W3125898896 cites W2165638033 @default.
• W3125898896 cites W2169303530 @default.
• W3125898896 cites W2430117556 @default.
• W3125898896 cites W2470094136 @default.
• W3125898896 cites W2511667040 @default.
• W3125898896 cites W2560322684 @default.
• W3125898896 cites W2600452401 @default.
• W3125898896 cites W2605772872 @default.
• W3125898896 cites W2762381618 @default.
• W3125898896 cites W2773163641 @default.
• W3125898896 cites W2791152362 @default.
• W3125898896 cites W2903803003 @default.
• W3125898896 cites W2909753989 @default.
• W3125898896 cites W2913565730 @default.
• W3125898896 cites W2937483840 @default.
• W3125898896 cites W2940712523 @default.
• W3125898896 cites W2944403040 @default.
• W3125898896 cites W3008219679 @default.
• W3125898896 cites W3027283245 @default.
• W3125898896 cites W4232534952 @default.
• W3125898896 doi "https://doi.org/10.3390/ph14020103" @default.
• W3125898896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7912319" @default.
• W3125898896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33572730" @default.
• W3125898896 hasPublicationYear "2021" @default.
• W3125898896 type Work @default.
• W3125898896 sameAs 3125898896 @default.
• W3125898896 citedByCount "9" @default.
• W3125898896 countsByYear W31258988962021 @default.
• W3125898896 countsByYear W31258988962022 @default.
• W3125898896 countsByYear W31258988962023 @default.
• W3125898896 crossrefType "journal-article" @default.
• W3125898896 hasAuthorship W3125898896A5025590518 @default.
• W3125898896 hasAuthorship W3125898896A5036498123 @default.
• W3125898896 hasAuthorship W3125898896A5078561219 @default.
• W3125898896 hasAuthorship W3125898896A5086697134 @default.
• W3125898896 hasAuthorship W3125898896A5087288813 @default.
• W3125898896 hasBestOaLocation W31258988961 @default.
• W3125898896 hasConcept C104317684 @default.
• W3125898896 hasConcept C121608353 @default.
• W3125898896 hasConcept C126322002 @default.
• W3125898896 hasConcept C185592680 @default.
• W3125898896 hasConcept C190283241 @default.
• W3125898896 hasConcept C2776438761 @default.
• W3125898896 hasConcept C2778305200 @default.
• W3125898896 hasConcept C2779723316 @default.
• W3125898896 hasConcept C2780192828 @default.
• W3125898896 hasConcept C29537977 @default.
• W3125898896 hasConcept C502942594 @default.
• W3125898896 hasConcept C55493867 @default.
• W3125898896 hasConcept C61367390 @default.
• W3125898896 hasConcept C62112901 @default.
• W3125898896 hasConcept C64927066 @default.
• W3125898896 hasConcept C71924100 @default.
• W3125898896 hasConcept C86803240 @default.
• W3125898896 hasConcept C96232424 @default.
• W3125898896 hasConceptScore W3125898896C104317684 @default.
• W3125898896 hasConceptScore W3125898896C121608353 @default.
• W3125898896 hasConceptScore W3125898896C126322002 @default.
• W3125898896 hasConceptScore W3125898896C185592680 @default.
• W3125898896 hasConceptScore W3125898896C190283241 @default.
• W3125898896 hasConceptScore W3125898896C2776438761 @default.
• W3125898896 hasConceptScore W3125898896C2778305200 @default.
• W3125898896 hasConceptScore W3125898896C2779723316 @default.
• W3125898896 hasConceptScore W3125898896C2780192828 @default.
• W3125898896 hasConceptScore W3125898896C29537977 @default.
• W3125898896 hasConceptScore W3125898896C502942594 @default.
• W3125898896 hasConceptScore W3125898896C55493867 @default.
• W3125898896 hasConceptScore W3125898896C61367390 @default.

• next