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- W3125925595 abstract "Background: Limited data were available for profiling the COVID-19 in pregnant women and their neonates. This study aimed to investigate the clinico-radiological findings and outcomes in pregnant women with COVID-19 compared to age-matched non-pregnant women, and assess the status of the neonates.Methods: Clinical and CT data of 21 pregnant and 19 age-matched non-pregnant women with COVID-19 from January 23 to March 4, 2020 were retrospectively reviewed. Four stages of CT images in both groups were analyzed and compared based on the time intervals from symptom onset: stage 1 (0-6 days, n=40), stage 2 (7-9 days, n=27), stage 3 (10-16 days, n=22), and stage 4 (>16, n=28). The clinical features and outcomes of the neonates were also assessed.Findings: Compared with age-matched non-pregnant women, initial normal temperature (13/21, 62%), leukocytosis (11/21, 52%), elevated neutrophil ratio (18 /21, 86%), and normal lymphocyte count (11/21, 52%) were more frequent in pregnant group. Pure consolidation in lungs was more common at presentation in pregnant cases (P<0·001). Pregnant women progressed with a higher consolidation frequency compared with non-pregnant group in stage 2 (95% vs. 82%, P=0·001). Improvement was identified in stages 3 and 4 for both groups, but consolidation was still more frequent for pregnant women in stage 4 (P<0·001). None of patients developed critical COVID-19 pneumonia or died in either group. Preterm delivery occurred in 6 of 16 (38%) patients. The pregnancy complications included intrauterine distress (n=1) and premature rupture of membrane (n=3). No neonatal asphyxia or death was observed. No infant had clinical COVID-19 pneumonia and pharyngeal swab specimens from 11 of 17 infants were negative for the SARS-CoV-2.Interpretation: Clinical features were not characteristic in pregnant women who developed relatively more severe COVID-19 pneumonia at presentation with a slower recovery course. Perinatal COVID-19 infection could potentially superimpose the risks of complications upon the mothers and their fetuses. Fortunately, the health status of neonates indicated that there was no evidence of the maternal-to-fetal transmission of COVID-19 in women during late pregnancy.Funding Statement: This study is funded by Joint fund project of Hubei Health Commission (WJ2019H294), National Key Research and Development Program of China (No. 2017YFC0109003), and Shanghai Sailing Program (19YF1433100).Declaration of Interests: The authors declare no competing interests.Ethics Approval Statement: This study was approved by the Institutional Ethics Committee of the two enrolled centers. The informed consent requirement was waived for this retrospective study." @default.
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- W3125925595 date "2020-01-01" @default.
- W3125925595 modified "2023-09-27" @default.
- W3125925595 title "Clinico-Radiological Features and Outcomes in Pregnant Women with COVID-19: Compared with Age-Matched Non-Pregnant Women" @default.
- W3125925595 doi "https://doi.org/10.2139/ssrn.3556647" @default.
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