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• W3125927921 abstract "Abstract BACKGROUND Purple corn ( Zea mays L.) is one of the main economic crops in China and has been used in the treatment of cystitis, urinary infections and obesity. However, purple corncobs, the by‐product remaining after processing and having an intense purple‐black color, are normally disposed of as waste or used as animal feed. Therefore, to further expand the medicinal value of purple corncob, its content was analyzed and, after purification, the effect and mechanism of purified purple corncob anthocyanins (PPCCA) on CCl 4 ‐induced chronic liver injury in mice were investigated. RESULTS It was observed that the total anthocyanin content (TAC) from PPCCA (317.51 ± 9.30 mg cyanidin 3‐ O ‐glucoside (C‐3‐G) g −1 dry weight) was significantly higher than that from the purified purple corn seed anthocyanin (266.73 ± 3.67 mg C‐3‐G g −1 dry weight), of which C‐3‐G accounted for 90.6% and 90.4% of the TAC, respectively. Furthermore, compared with the CCl 4 group, PPCCA treatment significantly reduced liver index, serum total bilirubin, alanine transaminase, aspartate transaminase and liver malondialdehyde levels, but increased liver superoxide dismutase activity. The pathological changes were also improved, such as more regular arrangement of hepatocytes, less swelling, and fewer vacuoles and apoptotic cells. Additionally, mechanistic studies showed that PPCCA downregulated the expression of Caspase‐3, Bax and cytochrome P450 2E1 proteins in the liver and upregulated the expression of Bcl‐2. CONCLUSION These results demonstrated that PPCCA could ameliorate CCl 4 ‐induced chronic liver injury by regulating oxidative stress and hepatocyte apoptosis pathways. © 2021 Society of Chemical Industry" @default.
• W3125927921 created "2021-02-01" @default.
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• W3125927921 date "2021-02-17" @default.
• W3125927921 modified "2023-10-17" @default.
• W3125927921 title "Purified anthocyanins from <scp> <i>Zea mays</i> </scp> L. cob ameliorates chronic liver injury in mice via modulating of oxidative stress and apoptosis" @default.
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• W3125927921 doi "https://doi.org/10.1002/jsfa.11112" @default.
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