FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125960007> ?p ?o ?g. }

• W3125960007 endingPage "1054" @default.
• W3125960007 startingPage "1054" @default.
• W3125960007 abstract "Glucocorticoid osteoporosis is a serious side effect of long term glucocorticoid uptake and it is caused by osteoblast apoptosis and imbalance in the major bone remodeling pathway RANK/RANKL/OPG. The impact of glucocorticoid on the maintenance of RANK/RANKL/OPG is well explored; dexamethasone was shown to disturb the ratio between OPG and RANKL level by decreasing the expression level of OPG and increasing level of RANKL. Here, were aimed to decipher whether glucocorticoid receptor directly influences RANKL promoter activity and its transcriptional regulation. We demonstrate that overexpression of glucocorticoid receptor (GR) NR3C1 increased RANKL promoter activity in human osteosarcoma, cervical cancer (2-fold) and adenocarcinoma cells (4.5-fold). Mutational analysis revealed that +352 site in the RANKL promoter is functional glucocorticoid responsive element (GRE) since the effect of GR on RANKL promoter activity was diminished by mutation at this site. Overexpression of NR3C1 upregulated RANKL mRNA expression 1.5-fold in human A549 and HOS cells. On the other hand silencing of NR3C1 caused slight decrease in RANKL mRNA level, suggesting that NR3C1 directly accounts for RANKL transcriptional regulation. Using electrophoretic mobility shift assay we demonstrate that NR3C1 binds to the proximal RANKL promoter region. Our study provides evidences that NR3C1 directly upregulates RANKL transcription in human cell lines and connects the missing link in the mechanism of RANK/RANKL/OPG imbalance of glucocorticoid induced osteoporosis." @default.
• W3125960007 created "2021-02-01" @default.
• W3125960007 creator A5012984040 @default.
• W3125960007 creator A5026779058 @default.
• W3125960007 date "2021-01-21" @default.
• W3125960007 modified "2023-09-26" @default.
• W3125960007 title "Glucocorticoid Receptor Regulates TNFSF11 Transcription by Binding to Glucocorticoid Responsive Element in TNFSF11 Proximal Promoter Region" @default.
• W3125960007 cites W1534645474 @default.
• W3125960007 cites W1795554369 @default.
• W3125960007 cites W1964914796 @default.
• W3125960007 cites W1971494641 @default.
• W3125960007 cites W1980418071 @default.
• W3125960007 cites W1987919183 @default.
• W3125960007 cites W1988694418 @default.
• W3125960007 cites W1995936060 @default.
• W3125960007 cites W1996028579 @default.
• W3125960007 cites W1999201913 @default.
• W3125960007 cites W2009721053 @default.
• W3125960007 cites W2010266168 @default.
• W3125960007 cites W2020765879 @default.
• W3125960007 cites W2034716448 @default.
• W3125960007 cites W2036368043 @default.
• W3125960007 cites W2043945700 @default.
• W3125960007 cites W2047425473 @default.
• W3125960007 cites W2048994674 @default.
• W3125960007 cites W2051255001 @default.
• W3125960007 cites W2051320963 @default.
• W3125960007 cites W2066869961 @default.
• W3125960007 cites W2067181732 @default.
• W3125960007 cites W2073739957 @default.
• W3125960007 cites W2086008590 @default.
• W3125960007 cites W2089139414 @default.
• W3125960007 cites W2089246265 @default.
• W3125960007 cites W2090932358 @default.
• W3125960007 cites W2113112889 @default.
• W3125960007 cites W2114394594 @default.
• W3125960007 cites W2120837197 @default.
• W3125960007 cites W2144258895 @default.
• W3125960007 cites W2146138547 @default.
• W3125960007 cites W2149248348 @default.
• W3125960007 cites W2153869151 @default.
• W3125960007 cites W2164042638 @default.
• W3125960007 cites W2171133944 @default.
• W3125960007 cites W2292034152 @default.
• W3125960007 cites W2568322374 @default.
• W3125960007 cites W2587219676 @default.
• W3125960007 cites W2767826728 @default.
• W3125960007 cites W2791691367 @default.
• W3125960007 cites W2794774376 @default.
• W3125960007 cites W2801554786 @default.
• W3125960007 cites W2803190702 @default.
• W3125960007 cites W2943208082 @default.
• W3125960007 cites W2967272506 @default.
• W3125960007 cites W2980970731 @default.
• W3125960007 cites W2984106671 @default.
• W3125960007 cites W3004103552 @default.
• W3125960007 cites W3015204213 @default.
• W3125960007 doi "https://doi.org/10.3390/ijms22031054" @default.
• W3125960007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7865994" @default.
• W3125960007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33494362" @default.
• W3125960007 hasPublicationYear "2021" @default.
• W3125960007 type Work @default.
• W3125960007 sameAs 3125960007 @default.
• W3125960007 citedByCount "3" @default.
• W3125960007 countsByYear W31259600072022 @default.
• W3125960007 crossrefType "journal-article" @default.
• W3125960007 hasAuthorship W3125960007A5012984040 @default.
• W3125960007 hasAuthorship W3125960007A5026779058 @default.
• W3125960007 hasBestOaLocation W31259600071 @default.
• W3125960007 hasConcept C126322002 @default.
• W3125960007 hasConcept C134018914 @default.
• W3125960007 hasConcept C170493617 @default.
• W3125960007 hasConcept C185592680 @default.
• W3125960007 hasConcept C2779428903 @default.
• W3125960007 hasConcept C2780841215 @default.
• W3125960007 hasConcept C502942594 @default.
• W3125960007 hasConcept C59493245 @default.
• W3125960007 hasConcept C71924100 @default.
• W3125960007 hasConcept C86803240 @default.
• W3125960007 hasConcept C88045685 @default.
• W3125960007 hasConceptScore W3125960007C126322002 @default.
• W3125960007 hasConceptScore W3125960007C134018914 @default.
• W3125960007 hasConceptScore W3125960007C170493617 @default.
• W3125960007 hasConceptScore W3125960007C185592680 @default.
• W3125960007 hasConceptScore W3125960007C2779428903 @default.
• W3125960007 hasConceptScore W3125960007C2780841215 @default.
• W3125960007 hasConceptScore W3125960007C502942594 @default.
• W3125960007 hasConceptScore W3125960007C59493245 @default.
• W3125960007 hasConceptScore W3125960007C71924100 @default.
• W3125960007 hasConceptScore W3125960007C86803240 @default.
• W3125960007 hasConceptScore W3125960007C88045685 @default.
• W3125960007 hasFunder F4320322554 @default.
• W3125960007 hasIssue "3" @default.
• W3125960007 hasLocation W31259600071 @default.
• W3125960007 hasLocation W31259600072 @default.
• W3125960007 hasLocation W31259600073 @default.
• W3125960007 hasLocation W31259600074 @default.
• W3125960007 hasLocation W31259600075 @default.

• next