Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125971890> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3125971890 endingPage "371" @default.
- W3125971890 startingPage "365" @default.
- W3125971890 abstract "Homeobox A10 (HOXA10) is a transcription factor belonging to the homeobox gene family. It is highly expressed in endometrial stromal cells (ESCs) and plays essential roles in the proliferation and differentiation of endometrium, the establishment of endometrial receptivity and embryo implantation. However, little is known about the target genes and signaling pathways regulated by HOXA10 in ESCs. In this study, we identified 1830 transcripts regulated by HOXA10 in ESCs by RNA interference (RNAi) and RNA-sequencing (RNA-seq) analysis, of which 980 were positively regulated by HOXA10 and 850 were negatively regulated by HOXA10. Interestingly, matrix metallopeptidase-11 was downregulated by HOXA10 in stromal cells verified by quantitative real-time polymerase chain reaction and western blot analysis. Pathway analysis demonstrated that the target genes were enriched in various pathways, including cellular metabolism, DNA replication and repair, cell junction, and lysosome and signal transduction. The results of the present study provide novel insights into the mechanism underlying HOXA10 regulation in ESCs and may identify novel targets for the diagnosis and treatment of endometrium-related infertility." @default.
- W3125971890 created "2021-02-01" @default.
- W3125971890 creator A5017774638 @default.
- W3125971890 creator A5028603894 @default.
- W3125971890 creator A5039002118 @default.
- W3125971890 creator A5083723295 @default.
- W3125971890 date "2021-01-01" @default.
- W3125971890 modified "2023-10-16" @default.
- W3125971890 title "Identification of HOXA10 target genes in human endometrial stromal cells by RNA-seq analysis" @default.
- W3125971890 cites W1921841154 @default.
- W3125971890 cites W1966922385 @default.
- W3125971890 cites W1982995152 @default.
- W3125971890 cites W1983522525 @default.
- W3125971890 cites W1983621519 @default.
- W3125971890 cites W1984831681 @default.
- W3125971890 cites W1987440412 @default.
- W3125971890 cites W2003143423 @default.
- W3125971890 cites W2003738260 @default.
- W3125971890 cites W2006494078 @default.
- W3125971890 cites W2030264114 @default.
- W3125971890 cites W2030973262 @default.
- W3125971890 cites W2049175197 @default.
- W3125971890 cites W2051150230 @default.
- W3125971890 cites W2051208397 @default.
- W3125971890 cites W2062574215 @default.
- W3125971890 cites W2072539890 @default.
- W3125971890 cites W2072840911 @default.
- W3125971890 cites W2092650651 @default.
- W3125971890 cites W2108949976 @default.
- W3125971890 cites W2129394604 @default.
- W3125971890 cites W2130463115 @default.
- W3125971890 cites W2153290165 @default.
- W3125971890 cites W2160327376 @default.
- W3125971890 doi "https://doi.org/10.1093/abbs/gmaa173" @default.
- W3125971890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33462609" @default.
- W3125971890 hasPublicationYear "2021" @default.
- W3125971890 type Work @default.
- W3125971890 sameAs 3125971890 @default.
- W3125971890 citedByCount "6" @default.
- W3125971890 countsByYear W31259718902021 @default.
- W3125971890 countsByYear W31259718902022 @default.
- W3125971890 countsByYear W31259718902023 @default.
- W3125971890 crossrefType "journal-article" @default.
- W3125971890 hasAuthorship W3125971890A5017774638 @default.
- W3125971890 hasAuthorship W3125971890A5028603894 @default.
- W3125971890 hasAuthorship W3125971890A5039002118 @default.
- W3125971890 hasAuthorship W3125971890A5083723295 @default.
- W3125971890 hasBestOaLocation W31259718901 @default.
- W3125971890 hasConcept C103652617 @default.
- W3125971890 hasConcept C104317684 @default.
- W3125971890 hasConcept C121587040 @default.
- W3125971890 hasConcept C166703698 @default.
- W3125971890 hasConcept C16930146 @default.
- W3125971890 hasConcept C502942594 @default.
- W3125971890 hasConcept C54355233 @default.
- W3125971890 hasConcept C67705224 @default.
- W3125971890 hasConcept C86339819 @default.
- W3125971890 hasConcept C86803240 @default.
- W3125971890 hasConcept C95444343 @default.
- W3125971890 hasConceptScore W3125971890C103652617 @default.
- W3125971890 hasConceptScore W3125971890C104317684 @default.
- W3125971890 hasConceptScore W3125971890C121587040 @default.
- W3125971890 hasConceptScore W3125971890C166703698 @default.
- W3125971890 hasConceptScore W3125971890C16930146 @default.
- W3125971890 hasConceptScore W3125971890C502942594 @default.
- W3125971890 hasConceptScore W3125971890C54355233 @default.
- W3125971890 hasConceptScore W3125971890C67705224 @default.
- W3125971890 hasConceptScore W3125971890C86339819 @default.
- W3125971890 hasConceptScore W3125971890C86803240 @default.
- W3125971890 hasConceptScore W3125971890C95444343 @default.
- W3125971890 hasFunder F4320321001 @default.
- W3125971890 hasIssue "3" @default.
- W3125971890 hasLocation W31259718901 @default.
- W3125971890 hasOpenAccess W3125971890 @default.
- W3125971890 hasPrimaryLocation W31259718901 @default.
- W3125971890 hasRelatedWork W1994194624 @default.
- W3125971890 hasRelatedWork W2021322256 @default.
- W3125971890 hasRelatedWork W2047141867 @default.
- W3125971890 hasRelatedWork W2057972383 @default.
- W3125971890 hasRelatedWork W2073615692 @default.
- W3125971890 hasRelatedWork W2280047479 @default.
- W3125971890 hasRelatedWork W2371126042 @default.
- W3125971890 hasRelatedWork W2526708792 @default.
- W3125971890 hasRelatedWork W4224309043 @default.
- W3125971890 hasRelatedWork W999239296 @default.
- W3125971890 hasVolume "53" @default.
- W3125971890 isParatext "false" @default.
- W3125971890 isRetracted "false" @default.
- W3125971890 magId "3125971890" @default.
- W3125971890 workType "article" @default.