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• W3125979553 startingPage "445" @default.
• W3125979553 abstract "Dequalinium chloride has been known as one kind of antibiotic that displays a broad antimicrobial spectrum and has been clinically proven to be very safe. In recent years, studies have shown that dequalinium chloride can inhibit the growth of malignant tumours, and reports were mainly used for solid tumours. Glioblastoma is the most common malignant neuroepithelial tumour of the central nervous system in adults, and the prognosis of glioblastoma is poor as it has a high resistance to apoptosis. This review summarizes the current understanding of dequalinium chloride-induced cancer cell apoptosis and its potential role in glioblastoma resistance and progression. Particularly, we focus on dequalinium chloride as it exerts a wide range of anti-cancer activity through its ability to target and accumulate in the mitochondria, and it effectively inhibits the growth of glioblastoma cells in vitro and vivo. Dequalinium chloride is an inhibitor of XIAP and can also act as a mitochondrial targeting agent, which gives it an interesting perspective regarding recent advances in the treatment of malignant glioma." @default.
• W3125979553 created "2021-02-01" @default.
• W3125979553 creator A5003322678 @default.
• W3125979553 creator A5004329784 @default.
• W3125979553 creator A5075013851 @default.
• W3125979553 date "2021-01-25" @default.
• W3125979553 modified "2023-10-16" @default.
• W3125979553 title "The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma" @default.
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