Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125989132> ?p ?o ?g. }
- W3125989132 abstract "Summary As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a mediator of mitochondrial retrograde signaling and a key transcriptional activator of nuclear-encoded mitochondrial genes in mammals. GPS2 regulated translocation from mitochondria to nucleus is essential for the transcriptional activation of the nuclear stress response to mitochondrial depolarization and for supporting basal mitochondrial biogenesis in differentiating adipocytes and in brown adipose tissue from mice. In the nucleus, GPS2 recruitment to target gene promoters regulates histone H3K9 demethylation and RNA Polymerase II (POL2) activation through inhibition of Ubc13-mediated ubiquitination. Together, these findings reveal an unexpected layer of regulation of mitochondrial gene transcription as they uncover a novel mitochondria-nuclear communication pathway." @default.
- W3125989132 created "2021-02-01" @default.
- W3125989132 creator A5000432967 @default.
- W3125989132 creator A5018574547 @default.
- W3125989132 creator A5032007543 @default.
- W3125989132 creator A5051174345 @default.
- W3125989132 creator A5061557079 @default.
- W3125989132 creator A5070376190 @default.
- W3125989132 creator A5071777328 @default.
- W3125989132 creator A5084631409 @default.
- W3125989132 creator A5090188206 @default.
- W3125989132 date "2017-07-11" @default.
- W3125989132 modified "2023-09-23" @default.
- W3125989132 title "GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes" @default.
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