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- W3126036615 abstract "Immunoengineering continues to revolutionize healthcare, generating new approaches for treating previously intractable diseases, particularly in regard to cancer immunotherapy. In joint diseases, such as osteoarthritis (OA) and rheumatoid arthritis (RA), biomaterials and anti-cytokine treatments have previously been at that forefront of therapeutic innovation. However, while many of the existing anti-cytokine treatments are successful for a subset of patients, these treatments can also pose severe risks due to adverse events and off-target effects due to continuous delivery at high dosages or a lack of disease-specific targets. These limitations have motivated the development of new treatment strategies that are well-controlled, precisely targeted, safe, and efficacious, all of which may be addressed with the application of direct and mechanistically-driven immunoengineering approaches. Advances in the understanding of the immunomodulatory pathways involved in musculoskeletal disease, in combination with the growing emphasis on personalized medicine, stress the need for carefully considering the delivery strategies and therapeutic targets when designing therapeutics to better treat RA and OA. Here, we focus on recent advances in biomaterial and cell-based immunomodulation, in combination with genetic engineering, for therapeutic applications in joint diseases. The application of immunoengineering principles to the study of joint disease will not only help to elucidate the mechanisms of disease pathogenesis but will also generate novel disease-specific therapeutics by harnessing cellular and biomaterial responses." @default.
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- W3126036615 date "2020-01-01" @default.
- W3126036615 modified "2023-10-14" @default.
- W3126036615 title "Immunoengineering the Next Generation of Arthritis Therapies" @default.
- W3126036615 doi "https://doi.org/10.2139/ssrn.3751569" @default.
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