Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126082010> ?p ?o ?g. }
- W3126082010 abstract "Significance SARS-CoV-2 is the causative agent of the COVID-19 pandemic. A molecular framework for how the virus manipulates host cellular machinery to facilitate infection is needed. Here, we integrate biochemical and single-molecule strategies to reveal molecular insight into how NSP1 from SARS-CoV-2 inhibits translation initiation. NSP1 directly binds to the small (40S) subunit of the human ribosome, which is modulated by human initiation factors. Further, NSP1 and mRNA compete with each other to bind the ribosome. Our findings suggest that the presence of NSP1 on the small ribosomal subunit prevents proper accommodation of the mRNA. How this competition disrupts the many steps of translation initiation is an important target for future studies." @default.
- W3126082010 created "2021-02-01" @default.
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- W3126082010 date "2021-01-21" @default.
- W3126082010 modified "2023-10-13" @default.
- W3126082010 title "Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation" @default.
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- W3126082010 doi "https://doi.org/10.1073/pnas.2017715118" @default.
- W3126082010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8017934" @default.
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