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- W3126171024 abstract "Organisms do not make the decision to feel hungry, but they can decide to satisfy, or to not satisfy, hunger. Consuming foods then maintains energy balance and can favor rewarding effects related to motivation to obtain food (“wanting”), defining eating behavior. In this context, this chapter describes part of the neural basis of eating behavior, focusing on critical action of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT4Rs) under stressful conditions. We found that 5-HT4Rs, located in an adaptive-decisive system (voluntary nervous system), including the medial prefrontal cortex and the nucleus accumbens, may favor rewarding and antidepressant effects of restrictive food intake (anorexia-like behavior). Here, we describe experimental procedures which have been associated in order to study a part of the neural bases underlying food intake following intracerebral infusion of pharmacological and nucleic treatments (siRNA, virus) in freely moving mice treated or not with a recreational drug of abuse (“ecstasy”). It includes the description of a micropunch technique required for analyzing specific downstream molecular events (cAMP: FRET, pCREB: Western blot, mRNA: RQ-PCR, binding sites: radioautography). Our conclusion introduces that processes within the voluntary nervous system (underlying decision, motivation) could be modified to prevail over a cerebral autonomous control (hypothalamus) of hunger, compromising survival. The 5-HT4Rs could be targeted with antagonist/inverse agonist combined to psychological approach to better cope with the stressors related to anorexia and drug dependence." @default.
- W3126171024 created "2021-02-15" @default.
- W3126171024 creator A5017059837 @default.
- W3126171024 date "2020-10-17" @default.
- W3126171024 modified "2023-09-23" @default.
- W3126171024 title "Exploring the Neural Underpinnings of an Antidepressant and Rewarding Action of Early Anorexia" @default.
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