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- W3126185278 abstract "In continuous pharmaceutical manufacturing, the degree of back-mixing has two contrary effects on the propagation of disturbances through a process. Firstly, back-mixing results in the contamination of adjacent material by strong disturbances and additional losses. However, the available measuring frequency in the process must detect all disturbances causing OOS material. Consequently, back-mixing must also smoothen out all undetectable disturbances. Therefore, we introduce the minimal needed measuring frequency and the mean loss in yield as indicators for the degree of back-mixing. In a case study, we utilize a dry granulation line from the literature and those indicators to discuss a strategy for the usage of multiple diversion points, the impact of uncertainties in measuring the degree of back-mixing, and setting operational parameters in the tablet press. This way, we reveal opportunities for reducing discharged material due to back-mixed disturbances in a continuous manufacturing line." @default.
- W3126185278 created "2021-02-15" @default.
- W3126185278 creator A5022122964 @default.
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- W3126185278 date "2021-04-01" @default.
- W3126185278 modified "2023-09-27" @default.
- W3126185278 title "Evaluating the potential for optimization of axial back-mixing in continuous pharmaceutical manufacturing" @default.
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- W3126185278 doi "https://doi.org/10.1016/j.compchemeng.2021.107251" @default.
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