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• W3126191350 endingPage "127841" @default.
• W3126191350 startingPage "127841" @default.
• W3126191350 abstract "A series of novel podophyllotoxin-naphthoquinone compounds 5a-p were synthesized in good yields using microwave-assisted four-component reactions of 2-hydroxy-1,4-naphthoquinone, aromatic benzaldehydes, tetronic acid and ammonium acetate. All the synthesized compounds were fully characterized by spectral data and evaluated for their cytotoxicity activities against KB, HepG2, Lu1, MCF7, and non-cancerous Hek-293 cell lines. Among 16 new compounds screened, compounds 5a, 5d, 5h, and 5k displayed high potent inhibitory activities with IC50 < 40 nM against HepG2 and SK-Lu-1 cell lines, and showed lower toxicity for non-cancerous Hek-293 cell line, demonstrating the potential importance of these compounds in the development of potential anticancer agents." @default.
• W3126191350 created "2021-02-15" @default.
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• W3126191350 date "2021-04-01" @default.
• W3126191350 modified "2023-10-12" @default.
• W3126191350 title "Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions" @default.
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• W3126191350 doi "https://doi.org/10.1016/j.bmcl.2021.127841" @default.
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