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• W3126198970 abstract "Abstract The existence of overlapping genes (OLGs) with significant coding overlaps revolutionises our understanding of genomic complexity. We report two exceptionally long (957 nt and 1536 nt), evolutionarily novel, translated antisense open reading frames (ORFs) embedded within annotated genes in the medically important Gram-negative bacterium Pseudomonas aeruginosa . Both OLG pairs show sequence features consistent with being genes and transcriptional signals in RNA sequencing data. Translation of both OLGs was confirmed by ribosome profiling and mass spectrometry. Quantitative proteomics of samples taken during different phases of growth revealed regulation of protein abundances, implying biological functionality. Both OLGs are taxonomically highly restricted, and likely arose by overprinting within the genus. Evidence for purifying selection further supports functionality. The OLGs reported here are the longest yet proposed in prokaryotes and are among the best attested in terms of translation and evolutionary constraint. These results highlight a potentially large unexplored dimension of prokaryotic genomes." @default.
• W3126198970 created "2021-02-15" @default.
• W3126198970 creator A5015767793 @default.
• W3126198970 creator A5020425391 @default.
• W3126198970 creator A5038703910 @default.
• W3126198970 creator A5063596187 @default.
• W3126198970 creator A5073323936 @default.
• W3126198970 creator A5090320822 @default.
• W3126198970 date "2021-02-10" @default.
• W3126198970 modified "2023-10-15" @default.
• W3126198970 title "Shadow ORFs illuminated: long overlapping genes in <i>Pseudomonas aeruginosa</i> are translated and under purifying selection" @default.
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