Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126204273> ?p ?o ?g. }
- W3126204273 abstract "The nematode C. elegans is a leading model to investigate the mechanisms of stress-induced behavioral changes coupled with biochemical mechanisms. Our group has previously characterized C. elegans behavior using a microfluidic-based electrotaxis device, and showed that worms display directional motion in the presence of a mild electric field. In this study, we describe the effects of various forms of genetic and environmental stress on the electrotactic movement of animals. Using exposure to chemicals, such as paraquat and tunicamycin, as well as mitochondrial and endoplasmic reticulum (ER) unfolded protein response (UPR) mutants, we demonstrate that chronic stress causes abnormal movement. Additionally, we report that pqe-1 (human RNA exonuclease 1 homolog) is necessary for the maintenance of multiple stress response signaling and electrotaxis behavior of animals. Further, exposure of C. elegans to several environmental stress-inducing conditions revealed that while chronic heat and dietary restriction caused electrotaxis speed deficits due to prolonged stress, daily exercise had a beneficial effect on the animals, likely due to improved muscle health and transient activation of UPR. Overall, these data demonstrate that the electrotaxis behavior of worms is susceptible to cytosolic, mitochondrial, and ER stress, and that multiple stress response pathways contribute to its preservation in the face of stressful stimuli." @default.
- W3126204273 created "2021-02-15" @default.
- W3126204273 creator A5014184827 @default.
- W3126204273 creator A5029917715 @default.
- W3126204273 creator A5043077080 @default.
- W3126204273 creator A5051988830 @default.
- W3126204273 creator A5054657289 @default.
- W3126204273 creator A5078587754 @default.
- W3126204273 date "2021-02-04" @default.
- W3126204273 modified "2023-09-30" @default.
- W3126204273 title "C. elegans electrotaxis behavior is modulated by heat shock response and unfolded protein response signaling pathways" @default.
- W3126204273 cites W1501762129 @default.
- W3126204273 cites W1556263878 @default.
- W3126204273 cites W1836312208 @default.
- W3126204273 cites W1944127002 @default.
- W3126204273 cites W1949402365 @default.
- W3126204273 cites W1965486589 @default.
- W3126204273 cites W1965843055 @default.
- W3126204273 cites W1972334626 @default.
- W3126204273 cites W1974522038 @default.
- W3126204273 cites W1974800864 @default.
- W3126204273 cites W1976654687 @default.
- W3126204273 cites W1979705609 @default.
- W3126204273 cites W1980699148 @default.
- W3126204273 cites W1981698771 @default.
- W3126204273 cites W1983772284 @default.
- W3126204273 cites W1987107881 @default.
- W3126204273 cites W1992634175 @default.
- W3126204273 cites W2006591185 @default.
- W3126204273 cites W2010097127 @default.
- W3126204273 cites W2012366379 @default.
- W3126204273 cites W2020335617 @default.
- W3126204273 cites W2023402149 @default.
- W3126204273 cites W2023676812 @default.
- W3126204273 cites W2028568142 @default.
- W3126204273 cites W2033258576 @default.
- W3126204273 cites W2039536853 @default.
- W3126204273 cites W2040484244 @default.
- W3126204273 cites W2041706288 @default.
- W3126204273 cites W2047495081 @default.
- W3126204273 cites W2056129497 @default.
- W3126204273 cites W2056544905 @default.
- W3126204273 cites W2064609969 @default.
- W3126204273 cites W2065929499 @default.
- W3126204273 cites W2071256705 @default.
- W3126204273 cites W2072117025 @default.
- W3126204273 cites W2074783650 @default.
- W3126204273 cites W2075743239 @default.
- W3126204273 cites W2077717792 @default.
- W3126204273 cites W2081284075 @default.
- W3126204273 cites W2085449884 @default.
- W3126204273 cites W2086324577 @default.
- W3126204273 cites W2086691574 @default.
- W3126204273 cites W2088685374 @default.
- W3126204273 cites W2088949307 @default.
- W3126204273 cites W2095518178 @default.
- W3126204273 cites W2111679957 @default.
- W3126204273 cites W2113636792 @default.
- W3126204273 cites W2118810495 @default.
- W3126204273 cites W2119146677 @default.
- W3126204273 cites W2121338998 @default.
- W3126204273 cites W2129277868 @default.
- W3126204273 cites W2140400644 @default.
- W3126204273 cites W2141444248 @default.
- W3126204273 cites W2152708819 @default.
- W3126204273 cites W2156172044 @default.
- W3126204273 cites W2184235212 @default.
- W3126204273 cites W2192080449 @default.
- W3126204273 cites W2255058527 @default.
- W3126204273 cites W2317877264 @default.
- W3126204273 cites W2334966793 @default.
- W3126204273 cites W2423217937 @default.
- W3126204273 cites W2461089329 @default.
- W3126204273 cites W2487443016 @default.
- W3126204273 cites W2502189175 @default.
- W3126204273 cites W2541605278 @default.
- W3126204273 cites W2560247106 @default.
- W3126204273 cites W2564232696 @default.
- W3126204273 cites W2585960379 @default.
- W3126204273 cites W2606022362 @default.
- W3126204273 cites W2625025106 @default.
- W3126204273 cites W2745264372 @default.
- W3126204273 cites W2762670382 @default.
- W3126204273 cites W2768090743 @default.
- W3126204273 cites W2770372563 @default.
- W3126204273 cites W2770644796 @default.
- W3126204273 cites W2784524393 @default.
- W3126204273 cites W2793897503 @default.
- W3126204273 cites W2806629750 @default.
- W3126204273 cites W2885431171 @default.
- W3126204273 cites W2888539854 @default.
- W3126204273 cites W2902812555 @default.
- W3126204273 cites W2904192199 @default.
- W3126204273 cites W2905384978 @default.
- W3126204273 cites W2917859676 @default.
- W3126204273 cites W2942087200 @default.
- W3126204273 cites W2968831837 @default.
- W3126204273 cites W2980194772 @default.
- W3126204273 cites W2984558615 @default.
- W3126204273 cites W3145751116 @default.