FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126206661> ?p ?o ?g. }

• W3126206661 abstract "Abstract Background Bacterial meningitis is a fatal disease with a mortality up to 30% and neurological sequelae in one fourth of survivors. Available vaccines do not fully protect against this lethal disease. Here, we report the protective effect of synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG ODN) against the most frequent form of bacterial meningitis caused by Streptococcus pneumoniae . Methods Three days prior to the induction of meningitis by intracerebral injection of S. pneumoniae D39, wild-type and Toll-like receptor (TLR9) −/− mice received an intraperitoneal injection of 100 μg CpG ODN or vehicle. To render mice neutropenic, anti-Ly-6G monoclonal antibody was daily administrated starting 4 days before infection with a total of 7 injections. Kaplan-Meier survival analyses and bacteriological studies, in which mice were sacrificed 24 h and 36 h after infection, were performed. Results Pre-treatment with 100 μg CpG ODN prolonged survival of immunocompetent and neutropenic wild-type mice but not of TLR9 −/− mice. There was a trend towards lower mortality in CpG ODN-treated immunocompetent and neutropenic wild-type mice. CpG ODN caused an increase of IL-12/IL-23p40 levels in the spleen and serum in uninfected animals. The effects of CpG ODN on bacterial concentrations and development of clinical symptoms were associated with an increased number of microglia in the CNS during the early phase of infection. Elevated concentrations of IL-12/IL-23p40 and MIP-1α correlated with lower bacterial concentrations in the blood and spleen during infection. Conclusions Pre-conditioning with CpG ODN strengthened the resistance of neutropenic and immunocompetent mice against S. pneumoniae meningitis in the presence of TLR9. Administration of CpG ODN decreased bacterial burden in the cerebellum and reduced the degree of bacteremia. Systemic administration of CpG ODN may help to prevent or slow the progression to sepsis of bacterial CNS infections in healthy and immunocompromised individuals even after direct inoculation of bacteria into the intracranial compartments, which can occur after sinusitis, mastoiditis, open head trauma, and surgery, including placement of an external ventricular drain." @default.
• W3126206661 created "2021-02-15" @default.
• W3126206661 creator A5008163071 @default.
• W3126206661 creator A5021990691 @default.
• W3126206661 creator A5022555219 @default.
• W3126206661 creator A5027292885 @default.
• W3126206661 creator A5037361363 @default.
• W3126206661 creator A5051117448 @default.
• W3126206661 creator A5062294579 @default.
• W3126206661 creator A5091573946 @default.
• W3126206661 date "2021-02-02" @default.
• W3126206661 modified "2023-09-27" @default.
• W3126206661 title "Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host" @default.
• W3126206661 cites W1514540900 @default.
• W3126206661 cites W1603278131 @default.
• W3126206661 cites W1832749456 @default.
• W3126206661 cites W1926496310 @default.
• W3126206661 cites W1966747326 @default.
• W3126206661 cites W1975663198 @default.
• W3126206661 cites W1976115338 @default.
• W3126206661 cites W1977921022 @default.
• W3126206661 cites W1991086765 @default.
• W3126206661 cites W1991862745 @default.
• W3126206661 cites W1995915955 @default.
• W3126206661 cites W2002353628 @default.
• W3126206661 cites W2009918976 @default.
• W3126206661 cites W2021369287 @default.
• W3126206661 cites W2022898219 @default.
• W3126206661 cites W2025134285 @default.
• W3126206661 cites W2032895269 @default.
• W3126206661 cites W2037860575 @default.
• W3126206661 cites W2040231381 @default.
• W3126206661 cites W205382369 @default.
• W3126206661 cites W2058777576 @default.
• W3126206661 cites W2062959887 @default.
• W3126206661 cites W2063172274 @default.
• W3126206661 cites W2074171762 @default.
• W3126206661 cites W2076753933 @default.
• W3126206661 cites W2081479062 @default.
• W3126206661 cites W2081655354 @default.
• W3126206661 cites W2085667648 @default.
• W3126206661 cites W2087003993 @default.
• W3126206661 cites W2095337891 @default.
• W3126206661 cites W2108054631 @default.
• W3126206661 cites W2109759840 @default.
• W3126206661 cites W2110223801 @default.
• W3126206661 cites W2110854960 @default.
• W3126206661 cites W2115515575 @default.
• W3126206661 cites W2116797415 @default.
• W3126206661 cites W2119524953 @default.
• W3126206661 cites W2125201285 @default.
• W3126206661 cites W2139624723 @default.
• W3126206661 cites W2142622291 @default.
• W3126206661 cites W2148356388 @default.
• W3126206661 cites W2165413779 @default.
• W3126206661 cites W2166055010 @default.
• W3126206661 cites W2168778790 @default.
• W3126206661 cites W2169875910 @default.
• W3126206661 cites W2326928530 @default.
• W3126206661 cites W2463347931 @default.
• W3126206661 cites W2495448885 @default.
• W3126206661 cites W2503107957 @default.
• W3126206661 cites W2529875271 @default.
• W3126206661 cites W2614588217 @default.
• W3126206661 cites W2783239992 @default.
• W3126206661 cites W2832414231 @default.
• W3126206661 cites W2896840254 @default.
• W3126206661 cites W2901883990 @default.
• W3126206661 cites W2914505546 @default.
• W3126206661 cites W2946872649 @default.
• W3126206661 doi "https://doi.org/10.1186/s12974-021-02077-3" @default.
• W3126206661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7852218" @default.
• W3126206661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33531028" @default.
• W3126206661 hasPublicationYear "2021" @default.
• W3126206661 type Work @default.
• W3126206661 sameAs 3126206661 @default.
• W3126206661 citedByCount "1" @default.
• W3126206661 countsByYear W31262066612021 @default.
• W3126206661 crossrefType "journal-article" @default.
• W3126206661 hasAuthorship W3126206661A5008163071 @default.
• W3126206661 hasAuthorship W3126206661A5021990691 @default.
• W3126206661 hasAuthorship W3126206661A5022555219 @default.
• W3126206661 hasAuthorship W3126206661A5027292885 @default.
• W3126206661 hasAuthorship W3126206661A5037361363 @default.
• W3126206661 hasAuthorship W3126206661A5051117448 @default.
• W3126206661 hasAuthorship W3126206661A5062294579 @default.
• W3126206661 hasAuthorship W3126206661A5091573946 @default.
• W3126206661 hasBestOaLocation W31262066611 @default.
• W3126206661 hasConcept C104317684 @default.
• W3126206661 hasConcept C118552586 @default.
• W3126206661 hasConcept C140173407 @default.
• W3126206661 hasConcept C150194340 @default.
• W3126206661 hasConcept C190727270 @default.
• W3126206661 hasConcept C203014093 @default.
• W3126206661 hasConcept C22801619 @default.
• W3126206661 hasConcept C2776914184 @default.
• W3126206661 hasConcept C2779138994 @default.
• W3126206661 hasConcept C2779830541 @default.
• W3126206661 hasConcept C2780931953 @default.
• W3126206661 hasConcept C2781026528 @default.

• next