Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126219783> ?p ?o ?g. }
- W3126219783 endingPage "1767" @default.
- W3126219783 startingPage "1767" @default.
- W3126219783 abstract "Multinucleate syncytialized trophoblast is found in three forms in the human placenta. In the earliest stages of pregnancy, it is seen at the invasive leading edge of the implanting embryo and has been called primitive trophoblast. In later pregnancy, it is represented by the immense, multinucleated layer covering the surface of placental villi and by the trophoblast giant cells found deep within the uterine decidua and myometrium. These syncytia interact with local and/or systemic maternal immune effector cells in a fine balance that allows for invasion and persistence of allogeneic cells in a mother who must retain immunocompetence for 40 weeks of pregnancy. Maternal immune interactions with syncytialized trophoblast require tightly regulated mechanisms that may differ depending on the location of fetal cells and their invasiveness, the nature of the surrounding immune effector cells and the gestational age of the pregnancy. Some specifically reflect the unique mechanisms involved in trophoblast cell–cell fusion (aka syncytialization). Here we will review and summarize several of the mechanisms that support healthy maternal–fetal immune interactions specifically at syncytiotrophoblast interfaces." @default.
- W3126219783 created "2021-02-15" @default.
- W3126219783 creator A5019232233 @default.
- W3126219783 creator A5023419188 @default.
- W3126219783 creator A5024963760 @default.
- W3126219783 creator A5025054004 @default.
- W3126219783 creator A5040981738 @default.
- W3126219783 creator A5042143593 @default.
- W3126219783 creator A5061547334 @default.
- W3126219783 date "2021-02-10" @default.
- W3126219783 modified "2023-10-01" @default.
- W3126219783 title "The Immunology of Syncytialized Trophoblast" @default.
- W3126219783 cites W11727725 @default.
- W3126219783 cites W1480887825 @default.
- W3126219783 cites W1510345640 @default.
- W3126219783 cites W1553328653 @default.
- W3126219783 cites W1571387405 @default.
- W3126219783 cites W1795119488 @default.
- W3126219783 cites W1893364625 @default.
- W3126219783 cites W1966316405 @default.
- W3126219783 cites W1966331087 @default.
- W3126219783 cites W1971528193 @default.
- W3126219783 cites W1971951822 @default.
- W3126219783 cites W1976410341 @default.
- W3126219783 cites W1978150606 @default.
- W3126219783 cites W1980405204 @default.
- W3126219783 cites W1981662437 @default.
- W3126219783 cites W1987188858 @default.
- W3126219783 cites W2005028798 @default.
- W3126219783 cites W2005765588 @default.
- W3126219783 cites W2010310827 @default.
- W3126219783 cites W2010332936 @default.
- W3126219783 cites W2015553570 @default.
- W3126219783 cites W2016329950 @default.
- W3126219783 cites W2016676597 @default.
- W3126219783 cites W2019888542 @default.
- W3126219783 cites W2021680265 @default.
- W3126219783 cites W2022250968 @default.
- W3126219783 cites W2023973806 @default.
- W3126219783 cites W2031923120 @default.
- W3126219783 cites W2032943068 @default.
- W3126219783 cites W2033059921 @default.
- W3126219783 cites W2042813472 @default.
- W3126219783 cites W2043991526 @default.
- W3126219783 cites W2047338466 @default.
- W3126219783 cites W2055313665 @default.
- W3126219783 cites W2056260975 @default.
- W3126219783 cites W2061446434 @default.
- W3126219783 cites W2061729961 @default.
- W3126219783 cites W2064720474 @default.
- W3126219783 cites W2065505347 @default.
- W3126219783 cites W2066083725 @default.
- W3126219783 cites W2074925828 @default.
- W3126219783 cites W2077240012 @default.
- W3126219783 cites W2084358775 @default.
- W3126219783 cites W2085435711 @default.
- W3126219783 cites W2094740097 @default.
- W3126219783 cites W2094761218 @default.
- W3126219783 cites W2097568705 @default.
- W3126219783 cites W2108942738 @default.
- W3126219783 cites W2112724873 @default.
- W3126219783 cites W2136533423 @default.
- W3126219783 cites W2140684477 @default.
- W3126219783 cites W2142600173 @default.
- W3126219783 cites W2150306998 @default.
- W3126219783 cites W2150475026 @default.
- W3126219783 cites W2157051716 @default.
- W3126219783 cites W2159356014 @default.
- W3126219783 cites W2159934585 @default.
- W3126219783 cites W2163703413 @default.
- W3126219783 cites W2163839814 @default.
- W3126219783 cites W2164027309 @default.
- W3126219783 cites W2164197794 @default.
- W3126219783 cites W2167924668 @default.
- W3126219783 cites W2170283143 @default.
- W3126219783 cites W2215460687 @default.
- W3126219783 cites W2283963041 @default.
- W3126219783 cites W2291449355 @default.
- W3126219783 cites W2324398577 @default.
- W3126219783 cites W2326233293 @default.
- W3126219783 cites W2332335459 @default.
- W3126219783 cites W2415342718 @default.
- W3126219783 cites W2472656114 @default.
- W3126219783 cites W2483938874 @default.
- W3126219783 cites W2496940829 @default.
- W3126219783 cites W2521898456 @default.
- W3126219783 cites W2523385016 @default.
- W3126219783 cites W2543278676 @default.
- W3126219783 cites W2543940717 @default.
- W3126219783 cites W2558287098 @default.
- W3126219783 cites W2588452414 @default.
- W3126219783 cites W2592215889 @default.
- W3126219783 cites W2601510444 @default.
- W3126219783 cites W2613142622 @default.
- W3126219783 cites W2754757163 @default.
- W3126219783 cites W2761099324 @default.
- W3126219783 cites W2763252130 @default.
- W3126219783 cites W2767784465 @default.