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- W3126253605 abstract "Abstract PurposeTo develop and validate an optimal timing protocol for a low-radiation-dose CT pulmonary perfusion technique using only two volume scans.MethodsA total of 24 swine (48.5 ± 14.3 kg) underwent contrast-enhanced dynamic CT. Multiple contrast injections were made under different pulmonary perfusion conditions, resulting in a total of 147 complete pulmonary arterial input functions(AIF). Using the AIFs, an optimal timing protocol for acquisition of two-volume scans was developed for the first-pass CT perfusion technique. Specifically, the first volume scan was obtained at the base of the AIF using bolus-tracking and the second volume scan was obtained at the peak of the AIF using a time-to-peak relation derived by regression analysis. Additionally, a subset of 14 swine with 60 CT acquisitions were used to validate the prospective timing protocol. The prospective perfusion measurements using the two-volume scans, were quantitatively compared to the retrospective perfusion measurements using the entire AIF with t-test, linear regression and Bland-Altman analysis. The CT dose index(CTDI 32 vol ) and size-specific dose estimate(SSDE) of the two-volume perfusion technique were also determined.ResultsThe pulmonary artery time-to-peak (T PA ) was related to one-half of the contrast injection duration(T Inj /2) by TPA = 1.06 T Inj /2+0.090 (r=0.97). Simulated prospective two-volume perfusion measurements (P PRO ) in ml/min/g were related to the retrospective measurements (P RETRO ) by P PRO = 0.87P RETRO + 0.56 (r=0.88). The CTDI 32 vol and SSDE of the two-volume CT technique were estimated to be 28.4 and 47.0mGy, respectively.ConclusionThe optimal timing protocol can enable an accurate, low-radiation-dose two-volume dynamic CT perfusion technique." @default.
- W3126253605 created "2021-02-15" @default.
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- W3126253605 date "2021-02-01" @default.
- W3126253605 modified "2023-09-27" @default.
- W3126253605 title "Two-Volume Dynamic CT Pulmonary Perfusion: Contrast Timing Optimization" @default.
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- W3126253605 doi "https://doi.org/10.21203/rs.3.rs-158655/v1" @default.
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