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- W3126255087 endingPage "101033" @default.
- W3126255087 startingPage "101033" @default.
- W3126255087 abstract "Breast cancer is the most common female cancer globally, with approximately 12% of patients eventually developing metastatic disease. Critically, limited effective treatment options exist for metastatic breast cancer. Recently, von Willebrand factor (VWF), a haemostatic plasma glycoprotein, has been shown to play an important role in tumour progression and metastasis. In breast cancer, a significant rise in the plasma levels of VWF has been reported in patients with malignant disease compared to benign conditions and healthy controls, with an even greater increase seen in patients with disseminated disease. Direct interactions between VWF, tumour cells, platelets and endothelial cells may promote haematogenous dissemination and thus the formation of metastatic foci. Intriguingly, patients with metastatic disease have unusually large VWF multimers. This observation has been proposed to be a result of a dysfunctional or deficiency of VWF-cleaving protease activity, ADAMTS-13 activity, which may then regulate the platelet-tumour adhesive interactions in the metastatic process. In this review, we provide an overview of VWF in orchestrating the pathological process of breast cancer dissemination, and provide supporting evidence of the role of VWF in mediating metastatic breast cancer." @default.
- W3126255087 created "2021-02-15" @default.
- W3126255087 creator A5034221629 @default.
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- W3126255087 creator A5089364466 @default.
- W3126255087 creator A5089913118 @default.
- W3126255087 creator A5091674670 @default.
- W3126255087 date "2021-04-01" @default.
- W3126255087 modified "2023-10-14" @default.
- W3126255087 title "The role of von Willebrand factor in breast cancer metastasis" @default.
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