FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126302198> ?p ?o ?g. }

• W3126302198 abstract "Abstract Probing endogenous molecular profiles is of fundamental importance to understand cellular function and processes. Despite the promise of programmable nucleic‐acid‐based aptasensors across the breadth of biomolecular detection, target‐responsive aptasensors enabling intracellular detection are as of yet infrequently realized. Several challenges remain, including the difficulties in quantification/normalization of quencher‐based intensiometric signals, stability issues of the probe architecture, and complex sensor operations often necessitating extensive structural modeling. Here, the biomimetic crystallization‐empowered self‐assembly of a tumor‐targetable DNA–inorganic hybrid nanocomposite aptasensor is presented, which enables Förster resonance energy transfer (FRET)‐based quantitative interpretation of changes in the cellular target abundance. Leveraging the design programmability and high‐throughput fabrication of rolling circle amplification‐driven DNA nanoarchitecture, this designer platform offers a method to self‐assemble a robust nanosensor from a multifunctionality‐encoded template that includes a cell‐targeting aptamer, a ratiometric aptasensor, and a cholesterol‐decorating element. Taking prostate cancer cells and intracellular adenosine triphosphate molecules as a model system, a synergistic effect in the targeted delivery by cholesterol and aptamers, and the feasibility of quantitative intracellular aptasensing are demonstrated. It is envisioned that this approach provides a highly generalizable strategy across wide‐ranging target systems toward a biologically deliverable nanosensor that enables quantitative monitoring of the abundance of endogenous biomolecules." @default.
• W3126302198 created "2021-02-15" @default.
• W3126302198 creator A5012037445 @default.
• W3126302198 creator A5012815077 @default.
• W3126302198 creator A5019256390 @default.
• W3126302198 creator A5044430674 @default.
• W3126302198 creator A5048228836 @default.
• W3126302198 creator A5081563073 @default.
• W3126302198 date "2021-02-08" @default.
• W3126302198 modified "2023-10-16" @default.
• W3126302198 title "Tumor‐Targeting Cholesterol‐Decorated DNA Nanoflowers for Intracellular Ratiometric Aptasensing" @default.
• W3126302198 cites W112835453 @default.
• W3126302198 cites W1970478438 @default.
• W3126302198 cites W1978871584 @default.
• W3126302198 cites W1986879990 @default.
• W3126302198 cites W1992683749 @default.
• W3126302198 cites W1996939713 @default.
• W3126302198 cites W1999671728 @default.
• W3126302198 cites W2004604806 @default.
• W3126302198 cites W2008845096 @default.
• W3126302198 cites W2015533291 @default.
• W3126302198 cites W2016431195 @default.
• W3126302198 cites W2022012719 @default.
• W3126302198 cites W2027107554 @default.
• W3126302198 cites W2031576029 @default.
• W3126302198 cites W2036226488 @default.
• W3126302198 cites W2037087042 @default.
• W3126302198 cites W2051699902 @default.
• W3126302198 cites W2054877253 @default.
• W3126302198 cites W2068167465 @default.
• W3126302198 cites W2097629605 @default.
• W3126302198 cites W2117817585 @default.
• W3126302198 cites W2119505328 @default.
• W3126302198 cites W2126012074 @default.
• W3126302198 cites W2137771729 @default.
• W3126302198 cites W2140022328 @default.
• W3126302198 cites W2157337481 @default.
• W3126302198 cites W2213085823 @default.
• W3126302198 cites W2229603522 @default.
• W3126302198 cites W2318409359 @default.
• W3126302198 cites W2334865985 @default.
• W3126302198 cites W2402094306 @default.
• W3126302198 cites W2490041812 @default.
• W3126302198 cites W2507131421 @default.
• W3126302198 cites W2534467129 @default.
• W3126302198 cites W2550392351 @default.
• W3126302198 cites W2587140557 @default.
• W3126302198 cites W2589774188 @default.
• W3126302198 cites W2611606035 @default.
• W3126302198 cites W2623017876 @default.
• W3126302198 cites W2757251766 @default.
• W3126302198 cites W2761777466 @default.
• W3126302198 cites W2780750565 @default.
• W3126302198 cites W2801300350 @default.
• W3126302198 cites W2804773381 @default.
• W3126302198 cites W2807093282 @default.
• W3126302198 cites W2808611866 @default.
• W3126302198 cites W2885041204 @default.
• W3126302198 cites W2894823011 @default.
• W3126302198 cites W2897379742 @default.
• W3126302198 cites W2900967223 @default.
• W3126302198 cites W2901603821 @default.
• W3126302198 cites W2904302631 @default.
• W3126302198 cites W2911573580 @default.
• W3126302198 cites W2914626251 @default.
• W3126302198 cites W2918203431 @default.
• W3126302198 cites W2938688854 @default.
• W3126302198 cites W2942904933 @default.
• W3126302198 cites W2946231052 @default.
• W3126302198 cites W2946501232 @default.
• W3126302198 cites W2952249183 @default.
• W3126302198 cites W2954935815 @default.
• W3126302198 cites W3035965385 @default.
• W3126302198 cites W890434135 @default.
• W3126302198 doi "https://doi.org/10.1002/adma.202007738" @default.
• W3126302198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7610848" @default.
• W3126302198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33554370" @default.
• W3126302198 hasPublicationYear "2021" @default.
• W3126302198 type Work @default.
• W3126302198 sameAs 3126302198 @default.
• W3126302198 citedByCount "29" @default.
• W3126302198 countsByYear W31263021982021 @default.
• W3126302198 countsByYear W31263021982022 @default.
• W3126302198 countsByYear W31263021982023 @default.
• W3126302198 crossrefType "journal-article" @default.
• W3126302198 hasAuthorship W3126302198A5012037445 @default.
• W3126302198 hasAuthorship W3126302198A5012815077 @default.
• W3126302198 hasAuthorship W3126302198A5019256390 @default.
• W3126302198 hasAuthorship W3126302198A5044430674 @default.
• W3126302198 hasAuthorship W3126302198A5048228836 @default.
• W3126302198 hasAuthorship W3126302198A5081563073 @default.
• W3126302198 hasBestOaLocation W31263021981 @default.
• W3126302198 hasConcept C121332964 @default.
• W3126302198 hasConcept C128972844 @default.
• W3126302198 hasConcept C137535248 @default.
• W3126302198 hasConcept C153911025 @default.
• W3126302198 hasConcept C160756335 @default.
• W3126302198 hasConcept C171250308 @default.
• W3126302198 hasConcept C192562407 @default.
• W3126302198 hasConcept C41858301 @default.

• next