FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126324189> ?p ?o ?g. }

• W3126324189 endingPage "1363" @default.
• W3126324189 startingPage "1355" @default.
• W3126324189 abstract "Abstract Objective To investigate the efficacy and mechanism of ultrasound-targeted microbubble destruction (UTMD) combined with radiotherapy (XRT) on glioblastoma. Methods The enhanced radiosensitization by UTMD was assessed through colony formation and cell apoptosis in Human glioblastoma cells (U87MG). Subcutaneous transplantation tumors in 24 nude mice implanted with U87MG cells were randomly assigned to 4 different treatment groups (Control, UTMD, XRT, and UTMD + XRT) based on tumor sizes (100–300 mm 3 ). Tumor growth was observed for 10 days after treatment, and then histopathology stains (HE, CD34, and γH2AX) were applied to the tumor samples. A TUNEL staining experiment was applied to detect the apoptosis rate of mice tumor samples. Meanwhile, tissue proteins were extracted from animal specimens, and the expressions of dsDNA break repair-related proteins from animal specimens were examined by the western blot. Results When the radiotherapy dose was 4 Gy, the colony formation rate of U87MG cells in the UTMD + XRT group was 32 ± 8%, lower than the XRT group (54 ± 14%, p < 0.01). The early apoptotic rate of the UTMD + XRT group was 21.1 ± 3% at 48 h, higher than that of the XRT group (15.2 ± 4%). The tumor growth curve indicated that the tumor growth was inhibited in the UTMD + XRT group compared with other groups during 10 days of observation. In TUNEL experiment, the apoptotic cells of the UTMD + XRT group were higher than that of the XRT group ( p < 0.05). The UTMD + XRT group had the lowest MVD value, but was not significantly different from other groups ( p > 0.05). In addition, γH2AX increased due to the addition of UTMD to radiotherapy compared to XRT in immunohistochemistry ( p < 0.05). Conclusions Our study clearly demonstrated the enhanced destructive effect of UTMD combined with 4 Gy radiotherapy on glioblastoma. This could be partly achieved by the increased ability of DNA damage of tumor cells." @default.
• W3126324189 created "2021-02-15" @default.
• W3126324189 creator A5007985766 @default.
• W3126324189 creator A5036427905 @default.
• W3126324189 creator A5037082892 @default.
• W3126324189 creator A5042528772 @default.
• W3126324189 creator A5049692788 @default.
• W3126324189 creator A5068732609 @default.
• W3126324189 creator A5069099445 @default.
• W3126324189 creator A5082710910 @default.
• W3126324189 date "2021-02-06" @default.
• W3126324189 modified "2023-09-27" @default.
• W3126324189 title "Using ultrasound-targeted microbubble destruction to enhance radiotherapy of glioblastoma" @default.
• W3126324189 cites W1526121022 @default.
• W3126324189 cites W1780348968 @default.
• W3126324189 cites W1866758872 @default.
• W3126324189 cites W1976374560 @default.
• W3126324189 cites W2001505041 @default.
• W3126324189 cites W2009733863 @default.
• W3126324189 cites W2026377273 @default.
• W3126324189 cites W2059066343 @default.
• W3126324189 cites W2060932390 @default.
• W3126324189 cites W2076898121 @default.
• W3126324189 cites W2098314742 @default.
• W3126324189 cites W2115538252 @default.
• W3126324189 cites W2120935644 @default.
• W3126324189 cites W2132809481 @default.
• W3126324189 cites W2134565735 @default.
• W3126324189 cites W2154424797 @default.
• W3126324189 cites W2163869065 @default.
• W3126324189 cites W2413689110 @default.
• W3126324189 cites W2499290919 @default.
• W3126324189 cites W2557705601 @default.
• W3126324189 cites W2564591209 @default.
• W3126324189 cites W2756960941 @default.
• W3126324189 cites W2768591361 @default.
• W3126324189 cites W2768759682 @default.
• W3126324189 cites W2791267538 @default.
• W3126324189 cites W2792407585 @default.
• W3126324189 cites W2792817321 @default.
• W3126324189 cites W2810085479 @default.
• W3126324189 cites W2838310729 @default.
• W3126324189 cites W2885243758 @default.
• W3126324189 cites W2902016504 @default.
• W3126324189 cites W2916378616 @default.
• W3126324189 cites W2921038907 @default.
• W3126324189 cites W2945466041 @default.
• W3126324189 cites W3033898594 @default.
• W3126324189 cites W4250899941 @default.
• W3126324189 doi "https://doi.org/10.1007/s00432-021-03542-5" @default.
• W3126324189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8021517" @default.
• W3126324189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33547949" @default.
• W3126324189 hasPublicationYear "2021" @default.
• W3126324189 type Work @default.
• W3126324189 sameAs 3126324189 @default.
• W3126324189 citedByCount "7" @default.
• W3126324189 countsByYear W31263241892021 @default.
• W3126324189 countsByYear W31263241892022 @default.
• W3126324189 countsByYear W31263241892023 @default.
• W3126324189 crossrefType "journal-article" @default.
• W3126324189 hasAuthorship W3126324189A5007985766 @default.
• W3126324189 hasAuthorship W3126324189A5036427905 @default.
• W3126324189 hasAuthorship W3126324189A5037082892 @default.
• W3126324189 hasAuthorship W3126324189A5042528772 @default.
• W3126324189 hasAuthorship W3126324189A5049692788 @default.
• W3126324189 hasAuthorship W3126324189A5068732609 @default.
• W3126324189 hasAuthorship W3126324189A5069099445 @default.
• W3126324189 hasAuthorship W3126324189A5082710910 @default.
• W3126324189 hasBestOaLocation W31263241891 @default.
• W3126324189 hasConcept C10205521 @default.
• W3126324189 hasConcept C126322002 @default.
• W3126324189 hasConcept C142724271 @default.
• W3126324189 hasConcept C190283241 @default.
• W3126324189 hasConcept C196795494 @default.
• W3126324189 hasConcept C204232928 @default.
• W3126324189 hasConcept C2778117688 @default.
• W3126324189 hasConcept C28328180 @default.
• W3126324189 hasConcept C2911091166 @default.
• W3126324189 hasConcept C2989005 @default.
• W3126324189 hasConcept C502942594 @default.
• W3126324189 hasConcept C509974204 @default.
• W3126324189 hasConcept C54355233 @default.
• W3126324189 hasConcept C544855455 @default.
• W3126324189 hasConcept C55493867 @default.
• W3126324189 hasConcept C71924100 @default.
• W3126324189 hasConcept C86803240 @default.
• W3126324189 hasConceptScore W3126324189C10205521 @default.
• W3126324189 hasConceptScore W3126324189C126322002 @default.
• W3126324189 hasConceptScore W3126324189C142724271 @default.
• W3126324189 hasConceptScore W3126324189C190283241 @default.
• W3126324189 hasConceptScore W3126324189C196795494 @default.
• W3126324189 hasConceptScore W3126324189C204232928 @default.
• W3126324189 hasConceptScore W3126324189C2778117688 @default.
• W3126324189 hasConceptScore W3126324189C28328180 @default.
• W3126324189 hasConceptScore W3126324189C2911091166 @default.
• W3126324189 hasConceptScore W3126324189C2989005 @default.
• W3126324189 hasConceptScore W3126324189C502942594 @default.
• W3126324189 hasConceptScore W3126324189C509974204 @default.

• next