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- W3126336240 abstract "Aim: The aim of this study was to explore the effects of ABCB1 and SLCO1B1 gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials & methods: Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for ABCB1 C3435T and SLCO1B1 T521C. Results: ABCB1 C3435T and SLCO1B1 T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients Conclusion: The selected ABCB1 and SLCO1B1 polymorphism do not predict the risk of MTX resistance in low-risk GTN." @default.
- W3126336240 created "2021-02-15" @default.
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- W3126336240 date "2021-03-01" @default.
- W3126336240 modified "2023-09-27" @default.
- W3126336240 title "<i>ABCB1</i> and <i>SLCO1B1</i> gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia" @default.
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- W3126336240 doi "https://doi.org/10.2217/pme-2020-0089" @default.
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