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• W3126367036 abstract "Anti-phospatidylserine/prothrombin (aPS/PT) antibodies have been described in cutaneous Polyarteritis Nodosa (PAN) in association with specific manifestations. To determine aPS/PT antibodies in patients with PAN and its correlation with clinical manifestations. Cross-sectional comparative study including PAN patients and 20 controls (10 Microscopic Polyangiitis [MPA] and 10 Behçet’s disease [BD]). Clinical and demographic variables, treatment, serologic markers, prognosis, activity and damage indexes were evaluated. aPS/PT, anti-cardiolipin (aCL), anti-beta 2 glycoprotein 1 (anti-B2GP1) antibodies, and lupus anticoagulant (LA) were determined. Fourteen patients with PAN were included, 11 (79%) women, with disease duration of 207 months, and mostly inactive disease. Only one patient with PAN and one with BD were positive for aPS/PT IgG. LA was the most frequent antibody identified. One patient with MPA and one with BD were positive for aCL IgM; one with MPA for anti-B2GP1 IgG, and one with PAN for anti-B2GP1 IgM. aPS/PT antibodies are not frequent in patients with longstanding inactive PAN. Anticuerpos anti-fosfatidilserina/protrombina (aPS/PT) han sido descritos en Poliarteritis Nodosa (PAN) cutánea, en asociación con manifestaciones específicas. Determinar anticuerpos aPS/PT en pacientes con PAN y analizar correlación con manifestaciones clínicas. Estudio transversal comparativo de pacientes con PAN y 20 controles (10 con Poliangeítis Microscópica [PAM] y 10 con Enfermedad de Behçet [EB]). Se evaluaron variables demográficas, clínicas, serológicas y tratamiento; índices de pronóstico, actividad y daño. Se determinaron anticuerpos aPS/PT, anti-cardiolipina (aCL), anti-beta 2 glicoproteína 1 (anti-B2GP1) y anticoagulante lúpico (AL). Catorce pacientes con PAN fueron incluidos, 11 (79%) mujeres, con duración de la enfermedad de 207 meses, y principalmente enfermedad inactiva. Sólo un paciente con PAN y uno con EB fueron positivos para aPS/PT IgG. El anticuerpo antifosfolípido más frecuente fue AL. Un paciente con PAM y uno con EB fueron positivos para aCL IgM; uno con PAM para anti-B2GP1 IgG, uno con PAN para anti-B2GP1 IgM. Los anticuerpos aPS/PT son infrecuentes en pacientes con PAN inactiva de larga evolución." @default.
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• W3126367036 date "2021-11-01" @default.
• W3126367036 modified "2023-10-18" @default.
• W3126367036 title "Anti-phosphatidylserine/prothrombin antibodies in patients with polyarteritis nodosa" @default.
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• W3126367036 doi "https://doi.org/10.1016/j.reumae.2020.05.005" @default.
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