FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126389973> ?p ?o ?g. }

• W3126389973 endingPage "1560" @default.
• W3126389973 startingPage "1560" @default.
• W3126389973 abstract "The interaction and crosstalk of Toll-like receptors (TLRs) is an established pathway in which the innate immune system recognises and fights pathogens. In a single nucleotide polymorphisms (SNP) analysis of an Indian cohort, we found evidence for both TLR4-399T and TRL8-1A conveying increased susceptibility towards tuberculosis (TB) in an interdependent manner, even though there is no established TLR4 ligand present in Mycobacterium tuberculosis (Mtb), which is the causative pathogen of TB. Docking studies revealed that TLR4 and TLR8 can build a heterodimer, allowing interaction with TLR8 ligands. The conformational change of TLR4-399T might impair this interaction. With immunoprecipitation and mass spectrometry, we precipitated TLR4 with TLR8-targeted antibodies, indicating heterodimerisation. Confocal microscopy confirmed a high co-localisation frequency of TLR4 and TLR8 that further increased upon TLR8 stimulation. The heterodimerisation of TLR4 and TLR8 led to an induction of IL12p40, NF-κB, and IRF3. TLR4-399T in interaction with TLR8 induced an increased NF-κB response as compared to TLR4-399C, which was potentially caused by an alteration of subsequent immunological pathways involving type I IFNs. In summary, we present evidence that the heterodimerisation of TLR4 and TLR8 at the endosome is involved in Mtb recognition via TLR8 ligands, such as microbial RNA, which induces a Th1 response. These findings may lead to novel targets for therapeutic interventions and vaccine development regarding TB." @default.
• W3126389973 created "2021-02-15" @default.
• W3126389973 creator A5000992769 @default.
• W3126389973 creator A5009349672 @default.
• W3126389973 creator A5015486088 @default.
• W3126389973 creator A5019830762 @default.
• W3126389973 creator A5024036236 @default.
• W3126389973 creator A5025961838 @default.
• W3126389973 creator A5033559732 @default.
• W3126389973 creator A5037115735 @default.
• W3126389973 creator A5048844194 @default.
• W3126389973 creator A5049684047 @default.
• W3126389973 creator A5050586206 @default.
• W3126389973 creator A5053887656 @default.
• W3126389973 creator A5075277153 @default.
• W3126389973 date "2021-02-04" @default.
• W3126389973 modified "2023-10-11" @default.
• W3126389973 title "Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis" @default.
• W3126389973 cites W1833923007 @default.
• W3126389973 cites W1972542500 @default.
• W3126389973 cites W1975640258 @default.
• W3126389973 cites W1992384164 @default.
• W3126389973 cites W1994364461 @default.
• W3126389973 cites W1995586746 @default.
• W3126389973 cites W2008329100 @default.
• W3126389973 cites W2012382096 @default.
• W3126389973 cites W2023481922 @default.
• W3126389973 cites W2037199116 @default.
• W3126389973 cites W2038554653 @default.
• W3126389973 cites W2045772297 @default.
• W3126389973 cites W2047365750 @default.
• W3126389973 cites W2065283382 @default.
• W3126389973 cites W2073382731 @default.
• W3126389973 cites W2080752012 @default.
• W3126389973 cites W2080810477 @default.
• W3126389973 cites W2083178837 @default.
• W3126389973 cites W2095833996 @default.
• W3126389973 cites W2105844209 @default.
• W3126389973 cites W2121469024 @default.
• W3126389973 cites W2125491088 @default.
• W3126389973 cites W2131900949 @default.
• W3126389973 cites W2143516276 @default.
• W3126389973 cites W2148537541 @default.
• W3126389973 cites W2151460035 @default.
• W3126389973 cites W2151777859 @default.
• W3126389973 cites W2156613610 @default.
• W3126389973 cites W2160805000 @default.
• W3126389973 cites W2161035695 @default.
• W3126389973 cites W2162422719 @default.
• W3126389973 cites W2162826697 @default.
• W3126389973 cites W2166516056 @default.
• W3126389973 cites W2167262253 @default.
• W3126389973 cites W2183361684 @default.
• W3126389973 cites W2195582449 @default.
• W3126389973 cites W2235759020 @default.
• W3126389973 cites W2463195069 @default.
• W3126389973 cites W2507791577 @default.
• W3126389973 cites W2735096245 @default.
• W3126389973 cites W2771683711 @default.
• W3126389973 cites W2789931212 @default.
• W3126389973 cites W2794843970 @default.
• W3126389973 cites W2795873846 @default.
• W3126389973 cites W2802285299 @default.
• W3126389973 cites W2804475258 @default.
• W3126389973 cites W2887956262 @default.
• W3126389973 cites W2898478236 @default.
• W3126389973 cites W2943334528 @default.
• W3126389973 cites W2945958075 @default.
• W3126389973 cites W3004681808 @default.
• W3126389973 cites W3012283572 @default.
• W3126389973 cites W3021577931 @default.
• W3126389973 cites W3022047971 @default.
• W3126389973 cites W3087077981 @default.
• W3126389973 cites W3102725912 @default.
• W3126389973 cites W4236842068 @default.
• W3126389973 doi "https://doi.org/10.3390/ijms22041560" @default.
• W3126389973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7913854" @default.
• W3126389973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33557133" @default.
• W3126389973 hasPublicationYear "2021" @default.
• W3126389973 type Work @default.
• W3126389973 sameAs 3126389973 @default.
• W3126389973 citedByCount "12" @default.
• W3126389973 countsByYear W31263899732022 @default.
• W3126389973 countsByYear W31263899732023 @default.
• W3126389973 crossrefType "journal-article" @default.
• W3126389973 hasAuthorship W3126389973A5000992769 @default.
• W3126389973 hasAuthorship W3126389973A5009349672 @default.
• W3126389973 hasAuthorship W3126389973A5015486088 @default.
• W3126389973 hasAuthorship W3126389973A5019830762 @default.
• W3126389973 hasAuthorship W3126389973A5024036236 @default.
• W3126389973 hasAuthorship W3126389973A5025961838 @default.
• W3126389973 hasAuthorship W3126389973A5033559732 @default.
• W3126389973 hasAuthorship W3126389973A5037115735 @default.
• W3126389973 hasAuthorship W3126389973A5048844194 @default.
• W3126389973 hasAuthorship W3126389973A5049684047 @default.
• W3126389973 hasAuthorship W3126389973A5050586206 @default.
• W3126389973 hasAuthorship W3126389973A5053887656 @default.
• W3126389973 hasAuthorship W3126389973A5075277153 @default.

• next