Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126405105> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3126405105 abstract "Abstract Background Pain in AS is currently considered an inflammatory pain (IP). However, it was found that some patients still had the sensation of pain even without inflammation. Our study was to investigate whether ankylosing spondylitis (AS) pain has a neuropathic pain (NeP) component. Methods The study consisted of three parts. The first included 182 AS patients to assess neuropathic pain in AS patients. The second included63 patients to evaluate pain improvement after etanercept therapy. The third included 20 AS patients and 10 healthy controls (HCs) to detect serum neurotransmitters. Results We found out that 55 paitents (30.21%) had possible NeP, and 14 (7.70%) had definite NeP. There were significant differences between the groups with respect to nocturnal pain (NP), peripheral pain (PP), total back pain (TBP), BASDAI, ASDAS-CRP, HAD-A, HAD-D and BASDAI-fatigue but not CRP concentrations. Principal component analysis (PCA) of AS pain revealed that the weight of NeP was greater than PP in the first principal component (0.703 vs 0.639). Structural equation modelling (SEM) revealed that NeP altered disease activity (β = 0.62, P < 0.001), which influenced psychological status (β = 0.42, P < 0.001). Of 63 patients who used etanercept for 3 months, significant improvement was found in NP, TBP and PP (all P < 0.0001) but not in PDQ (10.60 ± 6.85 vs 9.98 ± 6.40, P = 0.067). Serum norepinephrine concentrations in patients with positive PDQ were greater than those in patients with negative PDQ and HC. Conclusions We conclude that NeP contributes to pain in AS patients." @default.
- W3126405105 created "2021-02-15" @default.
- W3126405105 creator A5008103557 @default.
- W3126405105 creator A5018942295 @default.
- W3126405105 creator A5031097674 @default.
- W3126405105 creator A5036444950 @default.
- W3126405105 creator A5040587192 @default.
- W3126405105 creator A5042627775 @default.
- W3126405105 creator A5073101880 @default.
- W3126405105 creator A5073244521 @default.
- W3126405105 creator A5079003706 @default.
- W3126405105 creator A5080455100 @default.
- W3126405105 creator A5081944363 @default.
- W3126405105 date "2021-01-25" @default.
- W3126405105 modified "2023-09-27" @default.
- W3126405105 title "Neuropathic pain: a principal component of pain that should not be neglected in ankylosing spondylitis" @default.
- W3126405105 doi "https://doi.org/10.21203/rs.3.rs-153298/v1" @default.
- W3126405105 hasPublicationYear "2021" @default.
- W3126405105 type Work @default.
- W3126405105 sameAs 3126405105 @default.
- W3126405105 citedByCount "0" @default.
- W3126405105 crossrefType "posted-content" @default.
- W3126405105 hasAuthorship W3126405105A5008103557 @default.
- W3126405105 hasAuthorship W3126405105A5018942295 @default.
- W3126405105 hasAuthorship W3126405105A5031097674 @default.
- W3126405105 hasAuthorship W3126405105A5036444950 @default.
- W3126405105 hasAuthorship W3126405105A5040587192 @default.
- W3126405105 hasAuthorship W3126405105A5042627775 @default.
- W3126405105 hasAuthorship W3126405105A5073101880 @default.
- W3126405105 hasAuthorship W3126405105A5073244521 @default.
- W3126405105 hasAuthorship W3126405105A5079003706 @default.
- W3126405105 hasAuthorship W3126405105A5080455100 @default.
- W3126405105 hasAuthorship W3126405105A5081944363 @default.
- W3126405105 hasBestOaLocation W31264051051 @default.
- W3126405105 hasConcept C126322002 @default.
- W3126405105 hasConcept C17991360 @default.
- W3126405105 hasConcept C2776260265 @default.
- W3126405105 hasConcept C2777107010 @default.
- W3126405105 hasConcept C2777226972 @default.
- W3126405105 hasConcept C2777402515 @default.
- W3126405105 hasConcept C2777453003 @default.
- W3126405105 hasConcept C2779134260 @default.
- W3126405105 hasConcept C42219234 @default.
- W3126405105 hasConcept C71924100 @default.
- W3126405105 hasConcept C90924648 @default.
- W3126405105 hasConceptScore W3126405105C126322002 @default.
- W3126405105 hasConceptScore W3126405105C17991360 @default.
- W3126405105 hasConceptScore W3126405105C2776260265 @default.
- W3126405105 hasConceptScore W3126405105C2777107010 @default.
- W3126405105 hasConceptScore W3126405105C2777226972 @default.
- W3126405105 hasConceptScore W3126405105C2777402515 @default.
- W3126405105 hasConceptScore W3126405105C2777453003 @default.
- W3126405105 hasConceptScore W3126405105C2779134260 @default.
- W3126405105 hasConceptScore W3126405105C42219234 @default.
- W3126405105 hasConceptScore W3126405105C71924100 @default.
- W3126405105 hasConceptScore W3126405105C90924648 @default.
- W3126405105 hasLocation W31264051051 @default.
- W3126405105 hasOpenAccess W3126405105 @default.
- W3126405105 hasPrimaryLocation W31264051051 @default.
- W3126405105 hasRelatedWork W1581346817 @default.
- W3126405105 hasRelatedWork W2052900499 @default.
- W3126405105 hasRelatedWork W2072412214 @default.
- W3126405105 hasRelatedWork W2147166948 @default.
- W3126405105 hasRelatedWork W2148305943 @default.
- W3126405105 hasRelatedWork W2160730680 @default.
- W3126405105 hasRelatedWork W2183475026 @default.
- W3126405105 hasRelatedWork W2376526565 @default.
- W3126405105 hasRelatedWork W3127444029 @default.
- W3126405105 hasRelatedWork W4235629817 @default.
- W3126405105 isParatext "false" @default.
- W3126405105 isRetracted "false" @default.
- W3126405105 magId "3126405105" @default.
- W3126405105 workType "article" @default.