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- W3126408534 abstract "Abstract Background: Extended-spectrum β-lactamases (ESBLs)-producing strains of Klebsiella pneumoniae remain a critical clinical concern in the world. However, limited information is available concerning ESBLs-producing K. pneumoniae in giant pandas. The objective of this study was to characterize ESBLs-producing K. pneumoniae isolates from the giant panda. A total of 211 K. pneumoniae isolates were collected from 108 giant pandas housed at the Chengdu Research Base of Giant Panda Breeding, China. Samples were screened for the ESBLs-producing phenotype via the double-disk synergy test method. Result: A total of three (1.42%, n = 211) ESBLs-producing K. pneumoniae strains were identified and subjected to MLST (Multi-locus Sequence Typing) analysis for the characterization of ESBLs-encoding genes, transposons, antimicrobial resistance genes, and antimicrobial susceptibility. Among the three ESBLs-producing isolates, different ESBLs-encoding genes, including bla CTX-M-1 , bla SHV, and bla TEM were detected. Three isolates were found to carry transposons (i.e., aac6-ib and tnpU) and antimicrobial resistance genes (i.e., aac6-ib, tnpU, aac6-1, qnrA, and qnrB). Furthermore, these three isolates were resistant to at least 15 antibiotics and had different ST isotypes (ST37, ST290, and ST2640). Conclusion: Effective surveillance and strict infection control strategies should be implemented to prevent outbreaks of ESBLs-producing K. pneumoniae in giant panda." @default.
- W3126408534 created "2021-02-15" @default.
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- W3126408534 date "2021-02-01" @default.
- W3126408534 modified "2023-10-16" @default.
- W3126408534 title "Characterization of Extended-Spectrum β-Lactamases (ESBLs)-Producing Klebsiella Pneumoniae Strains in Captive Giant Pandas" @default.
- W3126408534 doi "https://doi.org/10.21203/rs.3.rs-144915/v1" @default.
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