FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126448857> ?p ?o ?g. }

• W3126448857 abstract "Abstract Obstructive sleep apnoea (OSA) is associated with type 2 diabetes mellitus (T2DM). However, mechanisms mediating association between these two conditions remain unclear. This study investigated, whether the OSA-associated changes in adipose tissue lipolysis might contribute to impaired glucose homeostasis in patient with T2DM. Thirty-five matched subjects were recruited into three groups: T2DM + severe OSA (T2DM + OSA, n = 11), T2DM with mild/no OSA (T2DM, n = 10) and healthy controls (n = 14). Subcutaneous abdominal adipose tissue microdialysis assessed spontaneous, epinephrine- and isoprenaline-stimulated lipolysis. Glucose metabolism was assessed by intravenous glucose tolerance test. Spontaneous lipolysis was higher in the T2DM + OSA compared with the T2DM (60.34 ± 23.40 vs. 42.53 ± 10.16 μmol/L, p = 0.013), as well as epinephrine-stimulated lipolysis (236.84 ± 103.90 vs. 167.39 ± 52.17 µmol/L, p < 0.001). Isoprenaline-stimulated lipolysis was unaffected by the presence of OSA ( p = 0.750). The α 2 anti-lipolytic effect was decreased in T2DM + OSA by 59% and 315% compared with T2DM and controls ( p = 0.045 and p = 0.007, respectively). The severity of OSA (AHI) was positively associated with spontaneous ( p = 0.037) and epinephrine-stimulated ( p = 0.026) lipolysis. The α 2 -adrenergic anti-lipolytic effect ( p = 0.043) decreased with increasing AHI. Spontaneous lipolysis was positively associated with Insulin resistance (r = 0.50, p = 0.002). Epinephrine-stimulated lipolysis was negatively associated with the Disposition index (r = − 0.34, p = 0.048). AHI was positively associated with Insulin resistance ( p = 0.017) and negatively with the Disposition index ( p = 0.038). Severe OSA in patients with T2DM increased adipose tissue lipolysis, probably due to inhibition of the α 2 -adrenergic anti-lipolytic effect. We suggest that dysregulated lipolysis might contribute to OSA-associated impairments in insulin secretion and sensitivity." @default.
• W3126448857 created "2021-02-15" @default.
• W3126448857 creator A5009476570 @default.
• W3126448857 creator A5012156319 @default.
• W3126448857 creator A5028538063 @default.
• W3126448857 creator A5047057260 @default.
• W3126448857 creator A5054264059 @default.
• W3126448857 creator A5063532587 @default.
• W3126448857 creator A5065512104 @default.
• W3126448857 creator A5068230593 @default.
• W3126448857 date "2021-02-11" @default.
• W3126448857 modified "2023-10-17" @default.
• W3126448857 title "Obstructive sleep apnoea increases lipolysis and deteriorates glucose homeostasis in patients with type 2 diabetes mellitus" @default.
• W3126448857 cites W121967333 @default.
• W3126448857 cites W1485905810 @default.
• W3126448857 cites W1559525331 @default.
• W3126448857 cites W1923677208 @default.
• W3126448857 cites W1947853286 @default.
• W3126448857 cites W1970787934 @default.
• W3126448857 cites W1974681300 @default.
• W3126448857 cites W1978804351 @default.
• W3126448857 cites W1980385296 @default.
• W3126448857 cites W1982398698 @default.
• W3126448857 cites W2000449344 @default.
• W3126448857 cites W2016168325 @default.
• W3126448857 cites W2018357617 @default.
• W3126448857 cites W2027358194 @default.
• W3126448857 cites W2028890388 @default.
• W3126448857 cites W2038349359 @default.
• W3126448857 cites W2041176514 @default.
• W3126448857 cites W2045018039 @default.
• W3126448857 cites W2049933070 @default.
• W3126448857 cites W2066041574 @default.
• W3126448857 cites W2068462373 @default.
• W3126448857 cites W2100784798 @default.
• W3126448857 cites W2105897677 @default.
• W3126448857 cites W2108078325 @default.
• W3126448857 cites W2108091559 @default.
• W3126448857 cites W2111528176 @default.
• W3126448857 cites W2111645882 @default.
• W3126448857 cites W2114510747 @default.
• W3126448857 cites W2116980144 @default.
• W3126448857 cites W2119275218 @default.
• W3126448857 cites W2122795688 @default.
• W3126448857 cites W2125842647 @default.
• W3126448857 cites W2137761211 @default.
• W3126448857 cites W2146561547 @default.
• W3126448857 cites W2149358180 @default.
• W3126448857 cites W2152593325 @default.
• W3126448857 cites W2153473929 @default.
• W3126448857 cites W2157559566 @default.
• W3126448857 cites W2161444884 @default.
• W3126448857 cites W2164122881 @default.
• W3126448857 cites W2167370342 @default.
• W3126448857 cites W2170495249 @default.
• W3126448857 cites W2170973387 @default.
• W3126448857 cites W2176172321 @default.
• W3126448857 cites W2261184724 @default.
• W3126448857 cites W2280346248 @default.
• W3126448857 cites W2291436268 @default.
• W3126448857 cites W2301058911 @default.
• W3126448857 cites W2316466067 @default.
• W3126448857 cites W23473646 @default.
• W3126448857 cites W2384198152 @default.
• W3126448857 cites W2465618666 @default.
• W3126448857 cites W2504965130 @default.
• W3126448857 cites W2513937502 @default.
• W3126448857 cites W2613483351 @default.
• W3126448857 cites W2622993844 @default.
• W3126448857 cites W2774743973 @default.
• W3126448857 cites W2791413126 @default.
• W3126448857 cites W2797432728 @default.
• W3126448857 cites W2897008849 @default.
• W3126448857 cites W3000192033 @default.
• W3126448857 cites W3001280065 @default.
• W3126448857 cites W3016263826 @default.
• W3126448857 cites W3036882857 @default.
• W3126448857 cites W3171237122 @default.
• W3126448857 cites W4235718181 @default.
• W3126448857 cites W4255242582 @default.
• W3126448857 cites W4376595732 @default.
• W3126448857 doi "https://doi.org/10.1038/s41598-021-83018-1" @default.
• W3126448857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7878919" @default.
• W3126448857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33574418" @default.
• W3126448857 hasPublicationYear "2021" @default.
• W3126448857 type Work @default.
• W3126448857 sameAs 3126448857 @default.
• W3126448857 citedByCount "9" @default.
• W3126448857 countsByYear W31264488572021 @default.
• W3126448857 countsByYear W31264488572022 @default.
• W3126448857 countsByYear W31264488572023 @default.
• W3126448857 crossrefType "journal-article" @default.
• W3126448857 hasAuthorship W3126448857A5009476570 @default.
• W3126448857 hasAuthorship W3126448857A5012156319 @default.
• W3126448857 hasAuthorship W3126448857A5028538063 @default.
• W3126448857 hasAuthorship W3126448857A5047057260 @default.
• W3126448857 hasAuthorship W3126448857A5054264059 @default.
• W3126448857 hasAuthorship W3126448857A5063532587 @default.
• W3126448857 hasAuthorship W3126448857A5065512104 @default.
• W3126448857 hasAuthorship W3126448857A5068230593 @default.

• next