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- W3126551428 endingPage "1358" @default.
- W3126551428 startingPage "1358" @default.
- W3126551428 abstract "Focal adhesions (FAs) serve as dynamic signaling hubs within the cell. They connect intracellular actin to the extracellular matrix (ECM) and respond to environmental cues. In doing so, these structures facilitate important processes such as cell–ECM adhesion and migration. Pathogenic microbes often modify the host cell actin cytoskeleton in their pursuit of an ideal replicative niche or during invasion to facilitate uptake. As actin-interfacing structures, FA dynamics are also intimately tied to actin cytoskeletal organization. Indeed, exploitation of FAs is another avenue by which pathogenic microbes ensure their uptake, survival and dissemination. This is often achieved through the secretion of effector proteins which target specific protein components within the FA. Molecular mimicry of the leucine–aspartic acid (LD) motif or vinculin-binding domains (VBDs) commonly found within FA proteins is a common microbial strategy. Other effectors may induce post-translational modifications to FA proteins through the regulation of phosphorylation sites or proteolytic cleavage. In this review, we present an overview of the regulatory mechanisms governing host cell FAs, and provide examples of how pathogenic microbes have evolved to co-opt them to their own advantage. Recent technological advances pose exciting opportunities for delving deeper into the mechanistic details by which pathogenic microbes modify FAs." @default.
- W3126551428 created "2021-02-15" @default.
- W3126551428 creator A5037786885 @default.
- W3126551428 creator A5070918931 @default.
- W3126551428 date "2021-01-29" @default.
- W3126551428 modified "2023-10-10" @default.
- W3126551428 title "Manipulation of Focal Adhesion Signaling by Pathogenic Microbes" @default.
- W3126551428 cites W1488960198 @default.
- W3126551428 cites W1490761102 @default.
- W3126551428 cites W1507456772 @default.
- W3126551428 cites W1510477000 @default.
- W3126551428 cites W1515202380 @default.
- W3126551428 cites W1519901358 @default.
- W3126551428 cites W1533711237 @default.
- W3126551428 cites W1559086192 @default.
- W3126551428 cites W1560179018 @default.
- W3126551428 cites W1588280167 @default.
- W3126551428 cites W1745418106 @default.
- W3126551428 cites W1745881199 @default.
- W3126551428 cites W1829553626 @default.
- W3126551428 cites W1836917794 @default.
- W3126551428 cites W1944220006 @default.
- W3126551428 cites W1964020745 @default.
- W3126551428 cites W1964145646 @default.
- W3126551428 cites W1964265166 @default.
- W3126551428 cites W1964695865 @default.
- W3126551428 cites W1966230719 @default.
- W3126551428 cites W1966835463 @default.
- W3126551428 cites W1966892912 @default.
- W3126551428 cites W1967089575 @default.
- W3126551428 cites W1967237098 @default.
- W3126551428 cites W1968815565 @default.
- W3126551428 cites W1970131417 @default.
- W3126551428 cites W1970882974 @default.
- W3126551428 cites W1971660947 @default.
- W3126551428 cites W1972035895 @default.
- W3126551428 cites W1972612436 @default.
- W3126551428 cites W1973528297 @default.
- W3126551428 cites W1975132186 @default.
- W3126551428 cites W1975473523 @default.
- W3126551428 cites W1975723984 @default.
- W3126551428 cites W1977791313 @default.
- W3126551428 cites W1979345371 @default.
- W3126551428 cites W1980224636 @default.
- W3126551428 cites W1980316109 @default.
- W3126551428 cites W1980468009 @default.
- W3126551428 cites W1980554628 @default.
- W3126551428 cites W1981367189 @default.
- W3126551428 cites W1982435227 @default.
- W3126551428 cites W1983957728 @default.
- W3126551428 cites W1984614532 @default.
- W3126551428 cites W1984922164 @default.
- W3126551428 cites W1985934608 @default.
- W3126551428 cites W1987334422 @default.
- W3126551428 cites W1987341205 @default.
- W3126551428 cites W1988532871 @default.
- W3126551428 cites W1990963263 @default.
- W3126551428 cites W1991417434 @default.
- W3126551428 cites W1992685981 @default.
- W3126551428 cites W1994884772 @default.
- W3126551428 cites W1999114258 @default.
- W3126551428 cites W1999453285 @default.
- W3126551428 cites W1999996757 @default.
- W3126551428 cites W2000939282 @default.
- W3126551428 cites W2002596571 @default.
- W3126551428 cites W2004142977 @default.
- W3126551428 cites W2004199264 @default.
- W3126551428 cites W2005027841 @default.
- W3126551428 cites W2005305957 @default.
- W3126551428 cites W2005508074 @default.
- W3126551428 cites W2007719816 @default.
- W3126551428 cites W2009582775 @default.
- W3126551428 cites W2009702029 @default.
- W3126551428 cites W2009924947 @default.
- W3126551428 cites W2011073796 @default.
- W3126551428 cites W2012153529 @default.
- W3126551428 cites W2012652910 @default.
- W3126551428 cites W2013284293 @default.
- W3126551428 cites W2014397920 @default.
- W3126551428 cites W2014485319 @default.
- W3126551428 cites W2015095297 @default.
- W3126551428 cites W2015644058 @default.
- W3126551428 cites W2016153572 @default.
- W3126551428 cites W2017108007 @default.
- W3126551428 cites W2017426055 @default.
- W3126551428 cites W2019485073 @default.
- W3126551428 cites W2021053981 @default.
- W3126551428 cites W2022113253 @default.
- W3126551428 cites W2022541364 @default.
- W3126551428 cites W2023392069 @default.
- W3126551428 cites W2023901812 @default.
- W3126551428 cites W2024558947 @default.
- W3126551428 cites W2025609605 @default.
- W3126551428 cites W2028691987 @default.
- W3126551428 cites W2029085695 @default.
- W3126551428 cites W2029491270 @default.
- W3126551428 cites W2031117855 @default.
- W3126551428 cites W2032116260 @default.