FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126562414> ?p ?o ?g. }

• W3126562414 abstract "Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based patients with incident PD. Methods: Four hundred thirty-three patients and 417 controls from three longitudinal cohorts were included in the study. Disease progression was recorded annually for up to 9 years using the Unified Parkinson's Disease Rating Scale (UPDRS) or Mini-Mental State Examination. Genotypes for five variants within the SNCA locus (rs2870004, rs356182, rs5019538, rs356219, and rs763443) were determined. We studied the association between each variant and disease progression using linear mixed-effects regression models. Results: The clinical profile of the patients with PD at the point of diagnosis was highly uniform between genotype groups. The rs356219-GG genotype was associated with a higher UPDRS II score than A-allele carriers (β = 1.52; 95% confidence interval 0.10-2.95; p = 0.036), but no differences were observed in the rate of progression of the UPDRS II scores. rs356219-GG was also associated with a faster annual change in Mini-Mental State Examination score compared with A-carriers (β = 0.03; 95% confidence interval 0.00-0.06; p = 0.043). Conclusions: We show that the known PD-risk variant rs356219 has a minor effect on modifying disease progression, whereas no differences were associated with rs2870004, rs356182, rs5019538, and rs763443. These findings suggest that SNCA variants associated with PD risk may not be major driving factors to the clinical heterogeneity observed for PD." @default.
• W3126562414 created "2021-02-15" @default.
• W3126562414 creator A5005926970 @default.
• W3126562414 creator A5008346654 @default.
• W3126562414 creator A5029870055 @default.
• W3126562414 creator A5055705553 @default.
• W3126562414 creator A5059614624 @default.
• W3126562414 creator A5066691500 @default.
• W3126562414 creator A5071057396 @default.
• W3126562414 creator A5078678815 @default.
• W3126562414 creator A5083154337 @default.
• W3126562414 creator A5088583341 @default.
• W3126562414 date "2021-02-10" @default.
• W3126562414 modified "2023-10-17" @default.
• W3126562414 title "Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients" @default.
• W3126562414 cites W1598254921 @default.
• W3126562414 cites W1765655507 @default.
• W3126562414 cites W1847168837 @default.
• W3126562414 cites W1987003014 @default.
• W3126562414 cites W2008854521 @default.
• W3126562414 cites W2037142665 @default.
• W3126562414 cites W2058161128 @default.
• W3126562414 cites W2064233040 @default.
• W3126562414 cites W2064963539 @default.
• W3126562414 cites W2064996887 @default.
• W3126562414 cites W2070582048 @default.
• W3126562414 cites W2089085990 @default.
• W3126562414 cites W2131434127 @default.
• W3126562414 cites W2141459724 @default.
• W3126562414 cites W2148080316 @default.
• W3126562414 cites W2154787098 @default.
• W3126562414 cites W2165465283 @default.
• W3126562414 cites W2167311298 @default.
• W3126562414 cites W2464977649 @default.
• W3126562414 cites W2550411660 @default.
• W3126562414 cites W2566450482 @default.
• W3126562414 cites W2593272776 @default.
• W3126562414 cites W2678056474 @default.
• W3126562414 cites W2754278602 @default.
• W3126562414 cites W2806429701 @default.
• W3126562414 cites W2884309857 @default.
• W3126562414 cites W2888882143 @default.
• W3126562414 cites W2944993102 @default.
• W3126562414 cites W2959335923 @default.
• W3126562414 cites W2972719726 @default.
• W3126562414 cites W2986932567 @default.
• W3126562414 cites W2992485745 @default.
• W3126562414 cites W3014263424 @default.
• W3126562414 doi "https://doi.org/10.3389/fneur.2020.620585" @default.
• W3126562414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7902914" @default.
• W3126562414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33643180" @default.
• W3126562414 hasPublicationYear "2021" @default.
• W3126562414 type Work @default.
• W3126562414 sameAs 3126562414 @default.
• W3126562414 citedByCount "5" @default.
• W3126562414 countsByYear W31265624142022 @default.
• W3126562414 countsByYear W31265624142023 @default.
• W3126562414 crossrefType "journal-article" @default.
• W3126562414 hasAuthorship W3126562414A5005926970 @default.
• W3126562414 hasAuthorship W3126562414A5008346654 @default.
• W3126562414 hasAuthorship W3126562414A5029870055 @default.
• W3126562414 hasAuthorship W3126562414A5055705553 @default.
• W3126562414 hasAuthorship W3126562414A5059614624 @default.
• W3126562414 hasAuthorship W3126562414A5066691500 @default.
• W3126562414 hasAuthorship W3126562414A5071057396 @default.
• W3126562414 hasAuthorship W3126562414A5078678815 @default.
• W3126562414 hasAuthorship W3126562414A5083154337 @default.
• W3126562414 hasAuthorship W3126562414A5088583341 @default.
• W3126562414 hasBestOaLocation W31265624141 @default.
• W3126562414 hasConcept C104317684 @default.
• W3126562414 hasConcept C126322002 @default.
• W3126562414 hasConcept C135763542 @default.
• W3126562414 hasConcept C143998085 @default.
• W3126562414 hasConcept C207103383 @default.
• W3126562414 hasConcept C2779134260 @default.
• W3126562414 hasConcept C2779734285 @default.
• W3126562414 hasConcept C2908647359 @default.
• W3126562414 hasConcept C44249647 @default.
• W3126562414 hasConcept C54355233 @default.
• W3126562414 hasConcept C71924100 @default.
• W3126562414 hasConcept C72563966 @default.
• W3126562414 hasConcept C86803240 @default.
• W3126562414 hasConcept C99454951 @default.
• W3126562414 hasConceptScore W3126562414C104317684 @default.
• W3126562414 hasConceptScore W3126562414C126322002 @default.
• W3126562414 hasConceptScore W3126562414C135763542 @default.
• W3126562414 hasConceptScore W3126562414C143998085 @default.
• W3126562414 hasConceptScore W3126562414C207103383 @default.
• W3126562414 hasConceptScore W3126562414C2779134260 @default.
• W3126562414 hasConceptScore W3126562414C2779734285 @default.
• W3126562414 hasConceptScore W3126562414C2908647359 @default.
• W3126562414 hasConceptScore W3126562414C44249647 @default.
• W3126562414 hasConceptScore W3126562414C54355233 @default.
• W3126562414 hasConceptScore W3126562414C71924100 @default.
• W3126562414 hasConceptScore W3126562414C72563966 @default.
• W3126562414 hasConceptScore W3126562414C86803240 @default.
• W3126562414 hasConceptScore W3126562414C99454951 @default.
• W3126562414 hasFunder F4320309793 @default.
• W3126562414 hasFunder F4320320021 @default.
• W3126562414 hasFunder F4320320059 @default.

• next