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- W3126572310 abstract "Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration." @default.
- W3126572310 created "2021-02-15" @default.
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- W3126572310 date "2021-01-31" @default.
- W3126572310 modified "2023-10-15" @default.
- W3126572310 title "Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length" @default.
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- W3126572310 doi "https://doi.org/10.1007/s11357-020-00310-0" @default.
- W3126572310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8110654" @default.
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