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- W3126612400 abstract "The conserved nuclear receptor superfamily has crucial roles in many processes, including reproduction. Nuclear receptors with known roles in oogenesis have been studied mostly in the context of their ovary-intrinsic requirement. Recent studies in Drosophila, however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss, reduced GSC proliferation, early germline cyst death, slowed follicle growth and vitellogenic follicle degeneration. Tissue-specific knockdown experiments uncovered ovary-intrinsic and peripheral tissue requirements for Hr4 In the ovary, Hr4 is required in the niche for GSC proliferation and in the germline for GSC maintenance. Hr4 functions in muscles to promote GSC maintenance and follicle growth. The specific tissues that require Hr4 for survival of early germline cysts and vitellogenic follicles remain unidentified. These results add to the few examples of muscles controlling gametogenesis and expand our understanding of the complexity of nuclear receptor regulation of various aspects of oogenesis." @default.
- W3126612400 created "2021-02-15" @default.
- W3126612400 creator A5079932260 @default.
- W3126612400 creator A5081289403 @default.
- W3126612400 date "2021-03-01" @default.
- W3126612400 modified "2023-10-17" @default.
- W3126612400 title "Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of <i>Drosophila</i> oogenesis" @default.
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- W3126612400 doi "https://doi.org/10.1242/dev.198663" @default.
- W3126612400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7970067" @default.
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