Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126633744> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3126633744 endingPage "265" @default.
- W3126633744 startingPage "259" @default.
- W3126633744 abstract "Nafamostat mesilate (NFM) is used as an anticoagulant during hemodialysis in patients who have had complications due to hemorrhages. The formation of precipitates, which could lead to the interruption of hemodialysis has been reported when NFM is infused into blood during hemodialysis. We report herein on an examination of possible factors that could cause this. The effects of electrolytes such as phosphates, citrates or succinates on the formation of precipitates were examined by mixing NFM with aqueous solutions or plasma that contained these electrolytes. The formation of precipitates was observed in all electrolyte solutions when higher concentrations of NFM were mixed at around physiological pH. In the case of plasma, precipitates were observed when solutions containing higher concentrations of NFM were mixed with plasma that contained phosphate and citrate. In addition, the formation of precipitates under dynamic conditions where NFM was infused into flowing electrolyte solutions was also evaluated. The data suggested that such precipitates might be formed and disrupt the blood flow and/or an NFM infusion when NFM is infused into blood flowing in the hemodialysis circuit. The findings presented herein suggest the serum levels of anionic electrolytes (e.g., phosphate), the type of excipients present in pharmaceutical products (e.g., succinic acid or citric acid), the concentration of NFM used for the infusion or the rates of NFM infusion and blood flow are all factors that could affect precipitate formation during NFM infusions for hemodialysis." @default.
- W3126633744 created "2021-02-15" @default.
- W3126633744 creator A5005102682 @default.
- W3126633744 creator A5011469338 @default.
- W3126633744 creator A5026222199 @default.
- W3126633744 creator A5070210035 @default.
- W3126633744 creator A5075726569 @default.
- W3126633744 creator A5089540655 @default.
- W3126633744 date "2021-02-01" @default.
- W3126633744 modified "2023-10-13" @default.
- W3126633744 title "Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis" @default.
- W3126633744 cites W1506845398 @default.
- W3126633744 cites W2138575779 @default.
- W3126633744 cites W2266925606 @default.
- W3126633744 cites W2318488418 @default.
- W3126633744 cites W2324327812 @default.
- W3126633744 cites W2325799596 @default.
- W3126633744 cites W2329722222 @default.
- W3126633744 cites W2483570849 @default.
- W3126633744 cites W2608844820 @default.
- W3126633744 cites W2738579340 @default.
- W3126633744 cites W2774529359 @default.
- W3126633744 cites W2795500910 @default.
- W3126633744 cites W2905292013 @default.
- W3126633744 cites W3004479781 @default.
- W3126633744 cites W3027880418 @default.
- W3126633744 cites W3031330053 @default.
- W3126633744 cites W3033543683 @default.
- W3126633744 cites W3047063124 @default.
- W3126633744 doi "https://doi.org/10.1248/bpb.b20-00808" @default.
- W3126633744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33518678" @default.
- W3126633744 hasPublicationYear "2021" @default.
- W3126633744 type Work @default.
- W3126633744 sameAs 3126633744 @default.
- W3126633744 citedByCount "0" @default.
- W3126633744 crossrefType "journal-article" @default.
- W3126633744 hasAuthorship W3126633744A5005102682 @default.
- W3126633744 hasAuthorship W3126633744A5011469338 @default.
- W3126633744 hasAuthorship W3126633744A5026222199 @default.
- W3126633744 hasAuthorship W3126633744A5070210035 @default.
- W3126633744 hasAuthorship W3126633744A5075726569 @default.
- W3126633744 hasAuthorship W3126633744A5089540655 @default.
- W3126633744 hasBestOaLocation W31266337441 @default.
- W3126633744 hasConcept C126322002 @default.
- W3126633744 hasConcept C141071460 @default.
- W3126633744 hasConcept C147789679 @default.
- W3126633744 hasConcept C17525397 @default.
- W3126633744 hasConcept C178790620 @default.
- W3126633744 hasConcept C184651966 @default.
- W3126633744 hasConcept C185592680 @default.
- W3126633744 hasConcept C2777132085 @default.
- W3126633744 hasConcept C2778063415 @default.
- W3126633744 hasConcept C2779032678 @default.
- W3126633744 hasConcept C2780243291 @default.
- W3126633744 hasConcept C2781041046 @default.
- W3126633744 hasConcept C43617362 @default.
- W3126633744 hasConcept C55493867 @default.
- W3126633744 hasConcept C68801617 @default.
- W3126633744 hasConcept C71924100 @default.
- W3126633744 hasConceptScore W3126633744C126322002 @default.
- W3126633744 hasConceptScore W3126633744C141071460 @default.
- W3126633744 hasConceptScore W3126633744C147789679 @default.
- W3126633744 hasConceptScore W3126633744C17525397 @default.
- W3126633744 hasConceptScore W3126633744C178790620 @default.
- W3126633744 hasConceptScore W3126633744C184651966 @default.
- W3126633744 hasConceptScore W3126633744C185592680 @default.
- W3126633744 hasConceptScore W3126633744C2777132085 @default.
- W3126633744 hasConceptScore W3126633744C2778063415 @default.
- W3126633744 hasConceptScore W3126633744C2779032678 @default.
- W3126633744 hasConceptScore W3126633744C2780243291 @default.
- W3126633744 hasConceptScore W3126633744C2781041046 @default.
- W3126633744 hasConceptScore W3126633744C43617362 @default.
- W3126633744 hasConceptScore W3126633744C55493867 @default.
- W3126633744 hasConceptScore W3126633744C68801617 @default.
- W3126633744 hasConceptScore W3126633744C71924100 @default.
- W3126633744 hasIssue "2" @default.
- W3126633744 hasLocation W31266337441 @default.
- W3126633744 hasOpenAccess W3126633744 @default.
- W3126633744 hasPrimaryLocation W31266337441 @default.
- W3126633744 hasRelatedWork W11380834 @default.
- W3126633744 hasRelatedWork W18610608 @default.
- W3126633744 hasRelatedWork W19092718 @default.
- W3126633744 hasRelatedWork W20511201 @default.
- W3126633744 hasRelatedWork W23163778 @default.
- W3126633744 hasRelatedWork W24360319 @default.
- W3126633744 hasRelatedWork W32086296 @default.
- W3126633744 hasRelatedWork W36530712 @default.
- W3126633744 hasRelatedWork W36999587 @default.
- W3126633744 hasRelatedWork W24632413 @default.
- W3126633744 hasVolume "44" @default.
- W3126633744 isParatext "false" @default.
- W3126633744 isRetracted "false" @default.
- W3126633744 magId "3126633744" @default.
- W3126633744 workType "article" @default.