FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126702996> ?p ?o ?g. }

• W3126702996 endingPage "643" @default.
• W3126702996 startingPage "643" @default.
• W3126702996 abstract "Etoposide-platinum (EP) chemotherapy has long been the reference treatment for grade 3 neuroendocrine neoplasms (G3 NEN). However, G3 NEN are heterogeneous, including well-differentiated tumors (NET) and poorly differentiated large (LCNEC) or small (SCNEC) cell carcinomas, whose response to EP chemotherapy varies considerably. Our aim was to evaluate predictive biomarkers for the response to EP chemotherapy in G3 NEN. We retrospectively studied 89 patients with lung (42%) and digestive (58%) G3 NEN treated by EP chemotherapy between 2006 and 2020. All cases were centrally reviewed for cytomorphology/Ki-67 and immunohistochemistry of retinoblastoma protein (Rb)/p53/p16, analyzed using a semi-quantitative score. The absence of Rb staining (Rbinap) or the absence of very intense p53 staining (p53inap) were considered inappropriate. Rb staining was also studied as a quantitative marker, the best threshold being determined by ROC curve. Intense p16 staining (p16high) also suggested cell cycle dysregulation. Our primary endpoint was the objective response rate (ORR). We included 10 G3 NET, 31 LCNEC and 48 SCNEC, which showed ORR of 20%, 32% and 75%, respectively (NET vs. NEC, p = 0.040; LCNEC vs. SCNEC, p < 0.001). The ORR was significantly higher in NEN presenting with Rbinap (63% vs. 42%, p = 0.025) and p16high (66% vs. 35%, p = 0.006). Rb < 150 optimally identified responders (AUC = 0.657, p < 0.001). The ORR was 67% in Rb < 150 (vs. 25%, p = 0.005). On multivariate analysis, only Rb < 150 was independently associated with ORR (OR 4.16, 95% CI 1.11–15.53, p = 0.034). We confirm the heterogeneity of the response to EP treatment in G3 NEN. Rb < 150 was the best predictive biomarker for the response to EP, and p53 immunostaining had no additional value." @default.
• W3126702996 created "2021-02-15" @default.
• W3126702996 creator A5008482986 @default.
• W3126702996 creator A5009980652 @default.
• W3126702996 creator A5013143562 @default.
• W3126702996 creator A5015987727 @default.
• W3126702996 creator A5038626624 @default.
• W3126702996 creator A5040360907 @default.
• W3126702996 creator A5040609393 @default.
• W3126702996 creator A5042208385 @default.
• W3126702996 creator A5056853165 @default.
• W3126702996 creator A5060346666 @default.
• W3126702996 creator A5063103135 @default.
• W3126702996 date "2021-02-05" @default.
• W3126702996 modified "2023-10-18" @default.
• W3126702996 title "Biomarkers of Response to Etoposide-Platinum Chemotherapy in Patients with Grade 3 Neuroendocrine Neoplasms" @default.
• W3126702996 cites W1128593298 @default.
• W3126702996 cites W1840972930 @default.
• W3126702996 cites W1996339349 @default.
• W3126702996 cites W2023163806 @default.
• W3126702996 cites W2032953029 @default.
• W3126702996 cites W2037668591 @default.
• W3126702996 cites W2048171546 @default.
• W3126702996 cites W2049137769 @default.
• W3126702996 cites W2056959168 @default.
• W3126702996 cites W2064202684 @default.
• W3126702996 cites W2101156795 @default.
• W3126702996 cites W2102069788 @default.
• W3126702996 cites W2106604563 @default.
• W3126702996 cites W2116642110 @default.
• W3126702996 cites W2123060958 @default.
• W3126702996 cites W2161676563 @default.
• W3126702996 cites W2251438188 @default.
• W3126702996 cites W2264814212 @default.
• W3126702996 cites W2290138226 @default.
• W3126702996 cites W2294290225 @default.
• W3126702996 cites W2410568505 @default.
• W3126702996 cites W2467394509 @default.
• W3126702996 cites W2555044978 @default.
• W3126702996 cites W2570536455 @default.
• W3126702996 cites W2610009396 @default.
• W3126702996 cites W2621339296 @default.
• W3126702996 cites W2765973383 @default.
• W3126702996 cites W2766264211 @default.
• W3126702996 cites W2767334296 @default.
• W3126702996 cites W2767732645 @default.
• W3126702996 cites W2788637603 @default.
• W3126702996 cites W2792828274 @default.
• W3126702996 cites W2811710613 @default.
• W3126702996 cites W2981189343 @default.
• W3126702996 cites W3005199194 @default.
• W3126702996 cites W3012964752 @default.
• W3126702996 cites W3047877961 @default.
• W3126702996 cites W4367590677 @default.
• W3126702996 cites W3023111168 @default.
• W3126702996 doi "https://doi.org/10.3390/cancers13040643" @default.
• W3126702996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7915900" @default.
• W3126702996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33562726" @default.
• W3126702996 hasPublicationYear "2021" @default.
• W3126702996 type Work @default.
• W3126702996 sameAs 3126702996 @default.
• W3126702996 citedByCount "17" @default.
• W3126702996 countsByYear W31267029962021 @default.
• W3126702996 countsByYear W31267029962022 @default.
• W3126702996 countsByYear W31267029962023 @default.
• W3126702996 crossrefType "journal-article" @default.
• W3126702996 hasAuthorship W3126702996A5008482986 @default.
• W3126702996 hasAuthorship W3126702996A5009980652 @default.
• W3126702996 hasAuthorship W3126702996A5013143562 @default.
• W3126702996 hasAuthorship W3126702996A5015987727 @default.
• W3126702996 hasAuthorship W3126702996A5038626624 @default.
• W3126702996 hasAuthorship W3126702996A5040360907 @default.
• W3126702996 hasAuthorship W3126702996A5040609393 @default.
• W3126702996 hasAuthorship W3126702996A5042208385 @default.
• W3126702996 hasAuthorship W3126702996A5056853165 @default.
• W3126702996 hasAuthorship W3126702996A5060346666 @default.
• W3126702996 hasAuthorship W3126702996A5063103135 @default.
• W3126702996 hasBestOaLocation W31267029962 @default.
• W3126702996 hasConcept C104317684 @default.
• W3126702996 hasConcept C126322002 @default.
• W3126702996 hasConcept C142724271 @default.
• W3126702996 hasConcept C143998085 @default.
• W3126702996 hasConcept C204232928 @default.
• W3126702996 hasConcept C2776577112 @default.
• W3126702996 hasConcept C2776694085 @default.
• W3126702996 hasConcept C2778119113 @default.
• W3126702996 hasConcept C55493867 @default.
• W3126702996 hasConcept C71924100 @default.
• W3126702996 hasConcept C74864618 @default.
• W3126702996 hasConcept C86803240 @default.
• W3126702996 hasConcept C90924648 @default.
• W3126702996 hasConceptScore W3126702996C104317684 @default.
• W3126702996 hasConceptScore W3126702996C126322002 @default.
• W3126702996 hasConceptScore W3126702996C142724271 @default.
• W3126702996 hasConceptScore W3126702996C143998085 @default.
• W3126702996 hasConceptScore W3126702996C204232928 @default.
• W3126702996 hasConceptScore W3126702996C2776577112 @default.
• W3126702996 hasConceptScore W3126702996C2776694085 @default.

• next