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- W3126713579 abstract "To identify biomarkers predictive of desensitization to peanut in subjects undergoing sublingual immunotherapy (SLIT) for peanut allergy. We included 42 challenge-proven peanut-allergic subjects between 1-11 years of age who underwent 48 months of peanut SLIT. Double-blind, placebo-controlled food challenges (DBPCFC) to 5000 mg of peanut protein were done at completion of SLIT. Plasma from baseline and completion of SLIT was assayed for peanut-specific IgE and IgG4 in addition to IgE to peanut components assayed using the ISAC chip (Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, Ara h 9). After 48 months of SLIT, 15 subjects (35.7%) passed the DBPCFC. The 27 subjects who failed tolerated a mean of 1374 mg of peanut protein (range 100-2900). Peanut-specific IgG4 to IgE ratio (IgG4/IgE) after completion of SLIT positively correlated with amount tolerated at the 48-month DBPCFC (Kendall’s tau= 0.336, p= 0.004). At 48 months, Ara h 2 and Ara h 6 IgE negatively correlated with the tolerated amount (Ara h 2: Kendall’s tau= -0.277, p= 0.021; Ara h 6: Kendall’s tau= -0.333, p= 0.008). At baseline, only Ara h 2 negatively correlated with the tolerated amount (Kendall’s tau = -0.243, p=0.042). Baseline IgG4/IgE also positively correlated with amount tolerated at the 48-month DBPCFC (Kendall’s tau = 0.248, p=0.035). In our cohort, decreased Ara h 2- and 6-specific IgE and increased peanut IgG4/IgE were associated with larger amounts tolerated during DBPCFC and may be useful biomarkers for desensitization in subjects undergoing SLIT for peanut allergy." @default.
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- W3126713579 date "2021-02-01" @default.
- W3126713579 modified "2023-09-27" @default.
- W3126713579 title "Biomarkers for Desensitization in Patients Undergoing Sublingual Immunotherapy for Peanut Allergy" @default.
- W3126713579 doi "https://doi.org/10.1016/j.jaci.2020.12.406" @default.
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