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- W3126765863 abstract "Late-onset hypogonadism, resulting from deficiency in serum testosterone (T), affects the health and quality of life of millions of aging men. T is synthesized by Leydig cells (LCs) in response to luteinizing hormone (LH). LH binds LC plasma membrane receptors, inducing the formation of a supramolecular complex of cytosolic and mitochondrial proteins, the Steroidogenic InteracTomE (SITE). SITE proteins are involved in targeting cholesterol to CYP11A1 in the mitochondria, the first enzyme of the steroidogenic cascade. Cholesterol translocation is the rate-determining step in T formation. With aging, LC defects occur that include changes in SITE, an increasingly oxidative intracellular environment, and reduced androgen formation and serum T levels. T replacement therapy (TRT) will restore T levels, but reported side effects make it desirable to develop additional strategies for increasing T. One approach is to target LC protein-protein interactions and thus increase T production by the hypofunctional Leydig cells themselves." @default.
- W3126765863 created "2021-02-15" @default.
- W3126765863 creator A5041963598 @default.
- W3126765863 creator A5058801218 @default.
- W3126765863 date "2021-01-01" @default.
- W3126765863 modified "2023-09-24" @default.
- W3126765863 title "Leydig cell aging: Molecular mechanisms and treatments" @default.
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