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- W3126787480 abstract "Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenocysteine in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both, the E2F5 transcription regulatory pathway and the Ca2+/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising therapeutic target for various inflammation-associated diseases, but also shows that our network-guided approach can significantly aid in predicting new functions of the genes of interest." @default.
- W3126787480 created "2021-02-15" @default.
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- W3126787480 date "2020-01-01" @default.
- W3126787480 modified "2023-10-16" @default.
- W3126787480 title "Identification of VIMP as a Gene Inhibiting Cytokine Production in Human CD4+ Effector T Cells" @default.
- W3126787480 doi "https://doi.org/10.2139/ssrn.3664369" @default.
- W3126787480 hasPublicationYear "2020" @default.
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