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• W3126797718 endingPage "2007" @default.
• W3126797718 startingPage "1986" @default.
• W3126797718 abstract "Abstract Fetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant personal and societal loss, and there is no effective treatment for these disorders. Cerebellar neuropathology is common in FASD and causes aberrant cognitive and motor function. Ethanol‐induced neuroinflammation is believed to contribute to neuropathological sequelae of FASD, and was previously demonstrated in the cerebellum in animal models of FASD. We now demonstrate neuroinflammation persists in the cerebellum several days following cessation of ethanol treatment in an early postnatal mouse model, with meaningful implications for timing of therapeutic intervention in FASD. We also demonstrate by Sholl analysis that ethanol decreases ramification of microglia cell processes in cells located near the Purkinje cell layer but not those near the external granule cell layer. Ethanol did not alter the expression of anti‐inflammatory molecules or molecules that constitute NLRP1 and NLRP3 inflammasomes. Interestingly, ethanol decreased the expression of IL‐23a (P19) and IL‐12Rβ1 suggesting that ethanol may suppress IL‐12 and IL‐23 signaling. Fractalkine‐fractalkine receptor (CX3CL1‐CX3CR1) signaling is believed to suppress microglial activation and our demonstration that ethanol decreases CX3CL1 expression suggests that ethanol modulation of CX3CL1‐CX3CR1 signaling may contribute to cerebellar neuroinflammation and neuropathology. We demonstrate ethanol alters the expression of specific molecules in the cerebellum understudied in FASD, but crucial for immune responses. Ethanol increases the expression of NOX‐2 and NGP and decreases the expression of RAG1, NOS1, CD59a, S1PR5, PTPN22, GPR37, and Serpinb1b. These molecules represent a new horizon as potential targets for development of FASD therapy." @default.
• W3126797718 created "2021-02-15" @default.
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• W3126797718 date "2021-02-02" @default.
• W3126797718 modified "2023-10-10" @default.
• W3126797718 title "Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders" @default.
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• W3126797718 doi "https://doi.org/10.1002/jnr.24797" @default.
• W3126797718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8326304" @default.
• W3126797718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33533128" @default.
• W3126797718 hasPublicationYear "2021" @default.
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