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- W3126832020 abstract "The aim of this research work was to develop n-propyl gallate-encapsulated solid lipid nanoparticles (PG-SLNs) and load them into a hyaluronic acid (HA)-based hydrogel (HG) for intranasal delivery. Simple modified solvent injection technique was used for the preparation of the PG-SLNs via the quality-by design (QbD) approach. The optimized PG-SLNs, with an average hydrodynamic diameter of 103 ± 46.04 nm, polydispersity index (PDI) of 0.16 ± 0.001 and zeta potential of −36 ± 4.78 mV, were obtained. The percentage yield of PG-SLNs was found to be 80.78 ± 0.1%, with an encapsulation efficiency of 84 ± 0.5% and loading capacity of 60 ± 0.1%. In vitro drug release from the hydrogel-containing PG-SLNs showed sustained release profile with a lower burst effect (less than 20%) and controlled release to a greater extent within 720 min following diffusion-based release kinetics. The in vitro permeability studies showed the total permeation of PG from HG was 600 μg/cm2 within 60 min, showing significant permeation of PG. Findings of this work strongly emphasize that PG-SLNs-loaded hydrogel and permeation enhancer hold significant potential to be delivered through the intranasal route." @default.
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- W3126832020 date "2020-12-01" @default.
- W3126832020 modified "2023-09-26" @default.
- W3126832020 title "Development and Optimization of n-Propyl Gallate-Encapsulated Hyaluronic Acid-Based Hydrogel for Nose-to-Brain Delivery Applying Quality-by-Design Methodology" @default.
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- W3126832020 doi "https://doi.org/10.3390/iecp2020-08707" @default.
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