FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126833332> ?p ?o ?g. }

• W3126833332 endingPage "342" @default.
• W3126833332 startingPage "325" @default.
• W3126833332 abstract "The aim of the present study was to investigate the pharmacological mechanism of matrine in treatment of COVID-19 combined with liver injury. Potential targets related to matrine, COVID-19 and liver injury were identified from several databases. We constructed PPI network and screened the core targets according to the degree value. Then, GO and KEGG enrichment were carried out. Molecular docking technology was used to verify the affinity between matrine and the crystal structure of core target protein. Finally, real-time RT-PCR was used to detect the effects of matrine on hub gene expression in liver tissue of liver injury mice and lung tissue of lung injury mice to further confirm the results of network pharmacological analysis. The results show that six core targets including AKT1, TP53, TNF, IL6, BCL2L1 and ATM were identified. The potential therapeutic mechanism of matrine on COVID-19 combined with liver injury is closely related to regulate antiviral process, improve immune system and regulate the level of inflammatory factors. Molecular docking showed that matrine could spontaneously bind to the receptor protein and had strong binding force. Real-time RT-PCR demonstrated that matrine could significantly reduce the expression of AKT1, TP53, TNF, IL6 and ATM in mice with liver injury or lung injury (P < 0.05), and increase the expression of BCL2L1 to a certain extent (P > 0.05). Our results indicate that matrine can achieve simultaneous intervention of COVID-19 combined with liver injury by multi-dimensional pharmacological mechanism." @default.
• W3126833332 created "2021-02-15" @default.
• W3126833332 creator A5009329280 @default.
• W3126833332 creator A5036188218 @default.
• W3126833332 creator A5037677450 @default.
• W3126833332 creator A5041001060 @default.
• W3126833332 creator A5049692788 @default.
• W3126833332 creator A5069269023 @default.
• W3126833332 creator A5087731341 @default.
• W3126833332 creator A5091510615 @default.
• W3126833332 date "2021-01-01" @default.
• W3126833332 modified "2023-10-05" @default.
• W3126833332 title "Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology" @default.
• W3126833332 cites W1270834676 @default.
• W3126833332 cites W2021865867 @default.
• W3126833332 cites W2034144554 @default.
• W3126833332 cites W2068596545 @default.
• W3126833332 cites W2090258227 @default.
• W3126833332 cites W2103017472 @default.
• W3126833332 cites W2104190143 @default.
• W3126833332 cites W2126103104 @default.
• W3126833332 cites W2144086069 @default.
• W3126833332 cites W2154139219 @default.
• W3126833332 cites W2159675211 @default.
• W3126833332 cites W2161239029 @default.
• W3126833332 cites W2313868977 @default.
• W3126833332 cites W2335512083 @default.
• W3126833332 cites W2362265365 @default.
• W3126833332 cites W2537623931 @default.
• W3126833332 cites W2537679995 @default.
• W3126833332 cites W2753107282 @default.
• W3126833332 cites W2886650285 @default.
• W3126833332 cites W2899291554 @default.
• W3126833332 cites W2902330400 @default.
• W3126833332 cites W2915806464 @default.
• W3126833332 cites W2945905480 @default.
• W3126833332 cites W2946412700 @default.
• W3126833332 cites W2974878186 @default.
• W3126833332 cites W3001118548 @default.
• W3126833332 cites W3001465255 @default.
• W3126833332 cites W3001897055 @default.
• W3126833332 cites W3002108456 @default.
• W3126833332 cites W3004949015 @default.
• W3126833332 cites W3006320625 @default.
• W3126833332 cites W3006643024 @default.
• W3126833332 cites W3006846061 @default.
• W3126833332 cites W3007189521 @default.
• W3126833332 cites W3007940623 @default.
• W3126833332 cites W3010637630 @default.
• W3126833332 cites W3025987322 @default.
• W3126833332 cites W3092515320 @default.
• W3126833332 doi "https://doi.org/10.1080/10717544.2021.1879313" @default.
• W3126833332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33517789" @default.
• W3126833332 hasPublicationYear "2021" @default.
• W3126833332 type Work @default.
• W3126833332 sameAs 3126833332 @default.
• W3126833332 citedByCount "24" @default.
• W3126833332 countsByYear W31268333322021 @default.
• W3126833332 countsByYear W31268333322022 @default.
• W3126833332 countsByYear W31268333322023 @default.
• W3126833332 crossrefType "journal-article" @default.
• W3126833332 hasAuthorship W3126833332A5009329280 @default.
• W3126833332 hasAuthorship W3126833332A5036188218 @default.
• W3126833332 hasAuthorship W3126833332A5037677450 @default.
• W3126833332 hasAuthorship W3126833332A5041001060 @default.
• W3126833332 hasAuthorship W3126833332A5049692788 @default.
• W3126833332 hasAuthorship W3126833332A5069269023 @default.
• W3126833332 hasAuthorship W3126833332A5087731341 @default.
• W3126833332 hasAuthorship W3126833332A5091510615 @default.
• W3126833332 hasBestOaLocation W31268333321 @default.
• W3126833332 hasConcept C118552586 @default.
• W3126833332 hasConcept C154137905 @default.
• W3126833332 hasConcept C159110408 @default.
• W3126833332 hasConcept C185592680 @default.
• W3126833332 hasConcept C2776545273 @default.
• W3126833332 hasConcept C2776637226 @default.
• W3126833332 hasConcept C41685203 @default.
• W3126833332 hasConcept C55493867 @default.
• W3126833332 hasConcept C62478195 @default.
• W3126833332 hasConcept C71924100 @default.
• W3126833332 hasConcept C86554907 @default.
• W3126833332 hasConcept C98274493 @default.
• W3126833332 hasConceptScore W3126833332C118552586 @default.
• W3126833332 hasConceptScore W3126833332C154137905 @default.
• W3126833332 hasConceptScore W3126833332C159110408 @default.
• W3126833332 hasConceptScore W3126833332C185592680 @default.
• W3126833332 hasConceptScore W3126833332C2776545273 @default.
• W3126833332 hasConceptScore W3126833332C2776637226 @default.
• W3126833332 hasConceptScore W3126833332C41685203 @default.
• W3126833332 hasConceptScore W3126833332C55493867 @default.
• W3126833332 hasConceptScore W3126833332C62478195 @default.
• W3126833332 hasConceptScore W3126833332C71924100 @default.
• W3126833332 hasConceptScore W3126833332C86554907 @default.
• W3126833332 hasConceptScore W3126833332C98274493 @default.
• W3126833332 hasFunder F4320321001 @default.
• W3126833332 hasIssue "1" @default.
• W3126833332 hasLocation W31268333321 @default.
• W3126833332 hasLocation W31268333322 @default.

• next