FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126834894> ?p ?o ?g. }

• W3126834894 endingPage "1306" @default.
• W3126834894 startingPage "1298" @default.
• W3126834894 abstract "ConspectusThe holy grail identified by Orgel in his 1995 Account was the development of novel chemical systems that evolve using reactions in which replication and information transfer occur together. There has been some success in the adaption of nucleic acids to make artificial analogues and in templating oligomerization reactions to form synthetic homopolymers, but replication of sequence information in synthetic polymers remains a major unsolved problem. In this Account, we describe our efforts in this direction based on a covalent base-pairing strategy to transfer sequence information between a parent template and a daughter copy. Oligotriazoles, which carry information as a sequence of phenol and benzoic acid side chains, have been prepared from bifunctional monomers equipped with an azide and an alkyne. Formation of esters between phenols and benzoic acids is used as the equivalent of nucleic base pairing to covalently attach monomer building blocks to a template oligomer. Sequential protection of the phenol side chains on the template, ester coupling of the benzoic acid side chains, and deprotection and ester coupling of the phenol side chains allow quantitative selective base-pair formation on a mixed sequence template. Copper catalyzed azide alkyne cycloaddition (CuAAC) is then used to oligomerize the monomers on the template. Finally, cleavage of the ester base pairs in the product duplex by hydrolysis releases the copy strand. This covalent template-directed synthesis strategy has been successfully used to copy the information encoded in a trimer template into a sequence-complementary oligomer in high yield.The use of covalent base pairing provides opportunities to manipulate the nature of the information transferred in the replication process. By using traceless linkers to connect the phenol and benzoic acid units, it is possible to carry out direct replication, reciprocal replication, and mutation. These preliminary results are promising, and methods have been developed to eliminate some of the side reactions that compete with the CuAAC process that zips up the duplex. In situ end-capping of the copy strand was found to be an effective general method for blocking intermolecular reactions between product duplexes. By selecting an appropriate concentration of an external capping agent, it is also possible to intercept macrocyclization of the reactive chain ends in the product duplex. The other side reaction observed is miscoupling of monomer units that are not attached to adjacent sites on the template, and optimization is required to eliminate these reactions. We are still some way from an evolvable synthetic polymer, but the chemical approach to molecular replication outlined here has some promise." @default.
• W3126834894 created "2021-02-15" @default.
• W3126834894 creator A5064693777 @default.
• W3126834894 creator A5080858872 @default.
• W3126834894 date "2021-02-06" @default.
• W3126834894 modified "2023-10-05" @default.
• W3126834894 title "Replication of Sequence Information in Synthetic Oligomers" @default.
• W3126834894 cites W1022309144 @default.
• W3126834894 cites W1966667200 @default.
• W3126834894 cites W1967595728 @default.
• W3126834894 cites W1968947723 @default.
• W3126834894 cites W1969492379 @default.
• W3126834894 cites W1975259432 @default.
• W3126834894 cites W2005914546 @default.
• W3126834894 cites W2007639251 @default.
• W3126834894 cites W2017950385 @default.
• W3126834894 cites W2030671459 @default.
• W3126834894 cites W2031409259 @default.
• W3126834894 cites W2044452478 @default.
• W3126834894 cites W2050183019 @default.
• W3126834894 cites W2053227072 @default.
• W3126834894 cites W2079321730 @default.
• W3126834894 cites W2083161790 @default.
• W3126834894 cites W2092102437 @default.
• W3126834894 cites W2092389668 @default.
• W3126834894 cites W2104525153 @default.
• W3126834894 cites W2104784856 @default.
• W3126834894 cites W2117755605 @default.
• W3126834894 cites W2126082941 @default.
• W3126834894 cites W2135557425 @default.
• W3126834894 cites W2139631118 @default.
• W3126834894 cites W2142447890 @default.
• W3126834894 cites W2277406536 @default.
• W3126834894 cites W2325253778 @default.
• W3126834894 cites W2493462109 @default.
• W3126834894 cites W2618900116 @default.
• W3126834894 cites W2902111471 @default.
• W3126834894 cites W2940818963 @default.
• W3126834894 cites W2949597917 @default.
• W3126834894 cites W2950996370 @default.
• W3126834894 cites W2973994242 @default.
• W3126834894 cites W2982970214 @default.
• W3126834894 cites W3129180445 @default.
• W3126834894 cites W4206595809 @default.
• W3126834894 cites W4237548661 @default.
• W3126834894 doi "https://doi.org/10.1021/acs.accounts.0c00852" @default.
• W3126834894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7931443" @default.
• W3126834894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33554599" @default.
• W3126834894 hasPublicationYear "2021" @default.
• W3126834894 type Work @default.
• W3126834894 sameAs 3126834894 @default.
• W3126834894 citedByCount "22" @default.
• W3126834894 countsByYear W31268348942021 @default.
• W3126834894 countsByYear W31268348942022 @default.
• W3126834894 countsByYear W31268348942023 @default.
• W3126834894 crossrefType "journal-article" @default.
• W3126834894 hasAuthorship W3126834894A5064693777 @default.
• W3126834894 hasAuthorship W3126834894A5080858872 @default.
• W3126834894 hasBestOaLocation W31268348941 @default.
• W3126834894 hasConcept C161790260 @default.
• W3126834894 hasConcept C166940927 @default.
• W3126834894 hasConcept C178790620 @default.
• W3126834894 hasConcept C180577832 @default.
• W3126834894 hasConcept C185581394 @default.
• W3126834894 hasConcept C185592680 @default.
• W3126834894 hasConcept C21951064 @default.
• W3126834894 hasConcept C2776403692 @default.
• W3126834894 hasConcept C2778112365 @default.
• W3126834894 hasConcept C2779546866 @default.
• W3126834894 hasConcept C2780443040 @default.
• W3126834894 hasConcept C2780642029 @default.
• W3126834894 hasConcept C2780997848 @default.
• W3126834894 hasConcept C521977710 @default.
• W3126834894 hasConcept C552990157 @default.
• W3126834894 hasConcept C55493867 @default.
• W3126834894 hasConceptScore W3126834894C161790260 @default.
• W3126834894 hasConceptScore W3126834894C166940927 @default.
• W3126834894 hasConceptScore W3126834894C178790620 @default.
• W3126834894 hasConceptScore W3126834894C180577832 @default.
• W3126834894 hasConceptScore W3126834894C185581394 @default.
• W3126834894 hasConceptScore W3126834894C185592680 @default.
• W3126834894 hasConceptScore W3126834894C21951064 @default.
• W3126834894 hasConceptScore W3126834894C2776403692 @default.
• W3126834894 hasConceptScore W3126834894C2778112365 @default.
• W3126834894 hasConceptScore W3126834894C2779546866 @default.
• W3126834894 hasConceptScore W3126834894C2780443040 @default.
• W3126834894 hasConceptScore W3126834894C2780642029 @default.
• W3126834894 hasConceptScore W3126834894C2780997848 @default.
• W3126834894 hasConceptScore W3126834894C521977710 @default.
• W3126834894 hasConceptScore W3126834894C552990157 @default.
• W3126834894 hasConceptScore W3126834894C55493867 @default.
• W3126834894 hasFunder F4320334627 @default.
• W3126834894 hasFunder F4320338335 @default.
• W3126834894 hasIssue "5" @default.
• W3126834894 hasLocation W31268348941 @default.
• W3126834894 hasLocation W31268348942 @default.
• W3126834894 hasOpenAccess W3126834894 @default.
• W3126834894 hasPrimaryLocation W31268348941 @default.

• next