FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126860145> ?p ?o ?g. }

• W3126860145 endingPage "254" @default.
• W3126860145 startingPage "247" @default.
• W3126860145 abstract "6-Hydroxydopamine (6-OHDA) is the most used toxin in experimental Parkinson's disease (PD) models. 6-OHDA shows high affinity for the dopamine transporter and once inside the neuron, it accumulates and undergoes non-enzymatic auto-oxidation, promoting reactive oxygen species (ROS) formation and selective damage of catecholaminergic neurons. In this way, our group has established a 6-OHDA in vitro protocol with rat striatal slices as a rapid and effective model for screening of new drugs with protective effects against PD. We have shown that co-incubation with guanosine (GUO, 100 μM) prevented the 6-OHDA-induced damage in striatal slices. As the exact GUO mechanism of action remains unknown, the aim of this study was to investigate if adenosine A1 (A1R) and/or A2A receptors (A2AR) are involved on GUO protective effects on striatal slices. Pre-incubation with DPCPX, an A1R antagonist prevented guanosine effects on 6-OHDA-induced ROS formation and mitochondrial membrane potential depolarization, while CCPA, an A1R agonist, did not alter GUO effects. Regarding A2AR, the antagonist SCH58261 had similar protective effect as GUO in ROS formation and mitochondrial membrane potential. Additionally, SCH58261 did not affect GUO protective effects. The A2AR agonist CGS21680, although, completely blocked GUO effects. Finally, the A1R antagonist DPCPX, and the A2AR agonist CGS21680 also abolished the preventive guanosine effect on 6-OHDA-induced ATP levels decrease. These results reinforce previous evidence for a putative interaction of GUO with A1R-A2AR heteromer as its molecular target and clearly indicate a dependence on adenosine receptors modulation to GUO protective effect." @default.
• W3126860145 created "2021-02-15" @default.
• W3126860145 creator A5007004833 @default.
• W3126860145 creator A5011233093 @default.
• W3126860145 creator A5014348946 @default.
• W3126860145 date "2021-02-06" @default.
• W3126860145 modified "2023-10-17" @default.
• W3126860145 title "Adenosine A1 and A2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices" @default.
• W3126860145 cites W1775749144 @default.
• W3126860145 cites W1972098832 @default.
• W3126860145 cites W1974026398 @default.
• W3126860145 cites W1980462043 @default.
• W3126860145 cites W1989467245 @default.
• W3126860145 cites W1994444726 @default.
• W3126860145 cites W2000461002 @default.
• W3126860145 cites W2002287054 @default.
• W3126860145 cites W2007635429 @default.
• W3126860145 cites W2009833011 @default.
• W3126860145 cites W2010060980 @default.
• W3126860145 cites W2010485061 @default.
• W3126860145 cites W2016397745 @default.
• W3126860145 cites W2016789150 @default.
• W3126860145 cites W2017190795 @default.
• W3126860145 cites W2033011398 @default.
• W3126860145 cites W2037673105 @default.
• W3126860145 cites W2050946838 @default.
• W3126860145 cites W2051506807 @default.
• W3126860145 cites W2054048077 @default.
• W3126860145 cites W2065444472 @default.
• W3126860145 cites W2073367434 @default.
• W3126860145 cites W2079079491 @default.
• W3126860145 cites W2086483799 @default.
• W3126860145 cites W2093406586 @default.
• W3126860145 cites W2099334527 @default.
• W3126860145 cites W2106307937 @default.
• W3126860145 cites W2118479885 @default.
• W3126860145 cites W2152165298 @default.
• W3126860145 cites W2168208715 @default.
• W3126860145 cites W2218976546 @default.
• W3126860145 cites W2229744007 @default.
• W3126860145 cites W23284523 @default.
• W3126860145 cites W2334581933 @default.
• W3126860145 cites W2416708726 @default.
• W3126860145 cites W2472172082 @default.
• W3126860145 cites W2519848766 @default.
• W3126860145 cites W2528308860 @default.
• W3126860145 cites W2563449272 @default.
• W3126860145 cites W2761736404 @default.
• W3126860145 cites W2762408661 @default.
• W3126860145 cites W2780238730 @default.
• W3126860145 cites W2803570575 @default.
• W3126860145 cites W2897142149 @default.
• W3126860145 cites W2901806837 @default.
• W3126860145 cites W2914257974 @default.
• W3126860145 cites W2955771175 @default.
• W3126860145 cites W2973210821 @default.
• W3126860145 cites W2995611030 @default.
• W3126860145 cites W2997997124 @default.
• W3126860145 cites W3045739415 @default.
• W3126860145 cites W4236341500 @default.
• W3126860145 cites W562575620 @default.
• W3126860145 doi "https://doi.org/10.1007/s11302-021-09765-y" @default.
• W3126860145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8155135" @default.
• W3126860145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33548045" @default.
• W3126860145 hasPublicationYear "2021" @default.
• W3126860145 type Work @default.
• W3126860145 sameAs 3126860145 @default.
• W3126860145 citedByCount "5" @default.
• W3126860145 countsByYear W31268601452022 @default.
• W3126860145 countsByYear W31268601452023 @default.
• W3126860145 crossrefType "journal-article" @default.
• W3126860145 hasAuthorship W3126860145A5007004833 @default.
• W3126860145 hasAuthorship W3126860145A5011233093 @default.
• W3126860145 hasAuthorship W3126860145A5014348946 @default.
• W3126860145 hasBestOaLocation W31268601452 @default.
• W3126860145 hasConcept C134018914 @default.
• W3126860145 hasConcept C170493617 @default.
• W3126860145 hasConcept C185592680 @default.
• W3126860145 hasConcept C2776885963 @default.
• W3126860145 hasConcept C2776991684 @default.
• W3126860145 hasConcept C2777995097 @default.
• W3126860145 hasConcept C2778938600 @default.
• W3126860145 hasConcept C2781225136 @default.
• W3126860145 hasConcept C513476851 @default.
• W3126860145 hasConcept C55493867 @default.
• W3126860145 hasConcept C67907053 @default.
• W3126860145 hasConcept C86803240 @default.
• W3126860145 hasConcept C98274493 @default.
• W3126860145 hasConceptScore W3126860145C134018914 @default.
• W3126860145 hasConceptScore W3126860145C170493617 @default.
• W3126860145 hasConceptScore W3126860145C185592680 @default.
• W3126860145 hasConceptScore W3126860145C2776885963 @default.
• W3126860145 hasConceptScore W3126860145C2776991684 @default.
• W3126860145 hasConceptScore W3126860145C2777995097 @default.
• W3126860145 hasConceptScore W3126860145C2778938600 @default.
• W3126860145 hasConceptScore W3126860145C2781225136 @default.
• W3126860145 hasConceptScore W3126860145C513476851 @default.
• W3126860145 hasConceptScore W3126860145C55493867 @default.

• next