FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126898739> ?p ?o ?g. }

• W3126898739 endingPage "241" @default.
• W3126898739 startingPage "241" @default.
• W3126898739 abstract "Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry. Our data indicate that MAIT cells are highly activated in patients with COVID-19, irrespective of the course of disease, and express high levels of proinflammatory cytokines such as IL-17A and TNFα ex vivo. Of note, expression of the activation marker HLA-DR positively correlated with SAPS II score, a measure of disease severity. Upon MAIT cell-specific in vitro stimulation, MAIT cells however failed to upregulate expression of the cytokines IL-17A and TNFα, as well as cytolytic proteins, that is, granzyme B and perforin. Thus, our data point towards an altered cytokine expression profile alongside an impaired antibacterial and antiviral function of MAIT cells in COVID-19 and thereby contribute to the understanding of COVID-19 immunopathogenesis." @default.
• W3126898739 created "2021-02-15" @default.
• W3126898739 creator A5006332308 @default.
• W3126898739 creator A5008345849 @default.
• W3126898739 creator A5009099523 @default.
• W3126898739 creator A5009402042 @default.
• W3126898739 creator A5011216679 @default.
• W3126898739 creator A5013132368 @default.
• W3126898739 creator A5029163782 @default.
• W3126898739 creator A5030518084 @default.
• W3126898739 creator A5035035416 @default.
• W3126898739 creator A5040038040 @default.
• W3126898739 creator A5042714073 @default.
• W3126898739 creator A5045306266 @default.
• W3126898739 creator A5045808037 @default.
• W3126898739 creator A5054375555 @default.
• W3126898739 creator A5062895290 @default.
• W3126898739 creator A5066208050 @default.
• W3126898739 creator A5068920358 @default.
• W3126898739 creator A5070875409 @default.
• W3126898739 creator A5076384284 @default.
• W3126898739 creator A5078974032 @default.
• W3126898739 creator A5079870396 @default.
• W3126898739 creator A5087926275 @default.
• W3126898739 date "2021-02-03" @default.
• W3126898739 modified "2023-09-23" @default.
• W3126898739 title "Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients" @default.
• W3126898739 cites W1505833426 @default.
• W3126898739 cites W1538607209 @default.
• W3126898739 cites W1825956709 @default.
• W3126898739 cites W1982688638 @default.
• W3126898739 cites W2003958237 @default.
• W3126898739 cites W2027160668 @default.
• W3126898739 cites W2042172298 @default.
• W3126898739 cites W2046153984 @default.
• W3126898739 cites W2049739427 @default.
• W3126898739 cites W2061593724 @default.
• W3126898739 cites W2065252029 @default.
• W3126898739 cites W2068487285 @default.
• W3126898739 cites W2119896120 @default.
• W3126898739 cites W2150492554 @default.
• W3126898739 cites W2162709457 @default.
• W3126898739 cites W2464020216 @default.
• W3126898739 cites W2545982909 @default.
• W3126898739 cites W2549209144 @default.
• W3126898739 cites W2783230342 @default.
• W3126898739 cites W2810207524 @default.
• W3126898739 cites W2886403363 @default.
• W3126898739 cites W2950937678 @default.
• W3126898739 cites W2974282920 @default.
• W3126898739 cites W2976456440 @default.
• W3126898739 cites W3001118548 @default.
• W3126898739 cites W3002108456 @default.
• W3126898739 cites W3007219306 @default.
• W3126898739 cites W3008090866 @default.
• W3126898739 cites W3008827533 @default.
• W3126898739 cites W3011976215 @default.
• W3126898739 cites W3013967887 @default.
• W3126898739 cites W3014003872 @default.
• W3126898739 cites W3021024241 @default.
• W3126898739 cites W3021544284 @default.
• W3126898739 cites W3023648440 @default.
• W3126898739 cites W3023991776 @default.
• W3126898739 cites W3032993667 @default.
• W3126898739 cites W3035094774 @default.
• W3126898739 cites W3041494167 @default.
• W3126898739 cites W3041667892 @default.
• W3126898739 cites W3042106384 @default.
• W3126898739 cites W3043433431 @default.
• W3126898739 cites W3047880178 @default.
• W3126898739 cites W3081906137 @default.
• W3126898739 cites W3088588389 @default.
• W3126898739 cites W3105548065 @default.
• W3126898739 doi "https://doi.org/10.3390/v13020241" @default.
• W3126898739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7913667" @default.
• W3126898739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33546489" @default.
• W3126898739 hasPublicationYear "2021" @default.
• W3126898739 type Work @default.
• W3126898739 sameAs 3126898739 @default.
• W3126898739 citedByCount "29" @default.
• W3126898739 countsByYear W31268987392021 @default.
• W3126898739 countsByYear W31268987392022 @default.
• W3126898739 countsByYear W31268987392023 @default.
• W3126898739 crossrefType "journal-article" @default.
• W3126898739 hasAuthorship W3126898739A5006332308 @default.
• W3126898739 hasAuthorship W3126898739A5008345849 @default.
• W3126898739 hasAuthorship W3126898739A5009099523 @default.
• W3126898739 hasAuthorship W3126898739A5009402042 @default.
• W3126898739 hasAuthorship W3126898739A5011216679 @default.
• W3126898739 hasAuthorship W3126898739A5013132368 @default.
• W3126898739 hasAuthorship W3126898739A5029163782 @default.
• W3126898739 hasAuthorship W3126898739A5030518084 @default.
• W3126898739 hasAuthorship W3126898739A5035035416 @default.
• W3126898739 hasAuthorship W3126898739A5040038040 @default.
• W3126898739 hasAuthorship W3126898739A5042714073 @default.
• W3126898739 hasAuthorship W3126898739A5045306266 @default.
• W3126898739 hasAuthorship W3126898739A5045808037 @default.
• W3126898739 hasAuthorship W3126898739A5054375555 @default.

• next