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- W3126935384 endingPage "167" @default.
- W3126935384 startingPage "151" @default.
- W3126935384 abstract "The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main functions include protein synthesis, proper protein folding, protein modification, and the transportation of synthesized proteins. Any perturbations in ER function, such as increased demand for protein folding or the accumulation of unfolded or misfolded proteins in the ER lumen, lead to a stress response called the unfolded protein response (UPR). The primary aim of the UPR is to restore cellular homeostasis; however, it triggers apoptotic signaling during prolonged stress. The core mechanisms of the ER stress response, the failure to respond to cellular stress, and the final fate of the cell are not yet clear. Here, we discuss cellular fate during ER stress, cross talk between the ER and mitochondria and its significance, and conditions that can trigger ER stress response failure. We also describe how the redox environment affects the ER stress response, and vice versa, and the aftermath of the ER stress response, integrating a discussion on redox imbalance-induced ER stress response failure progressing to cell death and dynamic pathophysiological changes." @default.
- W3126935384 created "2021-02-15" @default.
- W3126935384 creator A5041473993 @default.
- W3126935384 creator A5068304729 @default.
- W3126935384 creator A5077043027 @default.
- W3126935384 creator A5089567006 @default.
- W3126935384 date "2021-02-01" @default.
- W3126935384 modified "2023-10-17" @default.
- W3126935384 title "The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling" @default.
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