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• W3126948411 endingPage "750" @default.
• W3126948411 startingPage "750" @default.
• W3126948411 abstract "The anti-cancer antitumor antibiotic bleomycin(s) (BLM) induces athyminic sites in DNA after its activation, a process that results in strand splitting. Here, using A549 human lung cells or BEAS-2B cells lunc cells, we show that the cell toxicity of BLM can be suppressed by addition of inorganic polyphosphate (polyP), a physiological polymer that accumulates and is released from platelets. BLM at a concentration of 20 µg ml−1 causes a decrease in cell viability (by ~70%), accompanied by an increased DNA damage and chromatin expansion (by amazingly 6-fold). Importantly, the BLM-caused effects on cell growth and DNA integrity are substantially suppressed by polyP. In parallel, the enlargement of the nuclei/chromatin in BLM-treated cells (diameter, 20–25 µm) is normalized to ~12 µm after co-incubation of the cells with BLM and polyP. A sequential application of the drugs (BLM for 3 days, followed by an exposure to polyP) does not cause this normalization. During co-incubation of BLM with polyP the gene for the BLM hydrolase is upregulated. It is concluded that by upregulating this enzyme polyP prevents the toxic side effects of BLM. These data might also contribute to an application of BLM in COVID-19 patients, since polyP inhibits binding of SARS-CoV-2 to cellular ACE2." @default.
• W3126948411 created "2021-02-15" @default.
• W3126948411 creator A5034644142 @default.
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• W3126948411 creator A5086108824 @default.
• W3126948411 creator A5086389738 @default.
• W3126948411 date "2021-02-11" @default.
• W3126948411 modified "2023-09-26" @default.
• W3126948411 title "Polyphosphate Reverses the Toxicity of the Quasi-Enzyme Bleomycin on Alveolar Endothelial Lung Cells In Vitro" @default.
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• W3126948411 doi "https://doi.org/10.3390/cancers13040750" @default.
• W3126948411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7916961" @default.
• W3126948411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33670189" @default.
• W3126948411 hasPublicationYear "2021" @default.
• W3126948411 type Work @default.

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